Serine Proteases – Enzyme Catalysis von Kevin Ahern, PhD

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Über den Vortrag

Der Vortrag „Serine Proteases – Enzyme Catalysis“ von Kevin Ahern, PhD ist Bestandteil des Kurses „Physikum Zahnmedizin“.

Quiz zum Vortrag

  1. It lowers the energy of activation of a reaction.
  2. It changes the Gibbs free energy change of a reaction.
  3. Enzymes have constant, unmodulated activity.
  4. It allows reactions to go forward.
  1. They use serine for catalysis in their active sites.
  2. They cut target proteins at serine residues.
  3. They bind serine during catalysis.
  4. They are misnamed because they do not involve serine at all.
  1. Serine, histidine, and aspartic acid
  2. Serine, glutamic acid, and histidine
  3. Serine, glycine, and aspartic acid
  4. Serine, lysine, and histidine
  5. Serine, alanine, and selenocysteine
  1. Oxyanion hole
  2. Active site
  3. Allosteric site
  4. S1 pocket
  5. Hydroxide/alkoxide pocket
  1. S1 pocket
  2. Oxyanion hole
  3. Active site
  4. Allosteric site
  5. Alkoxide/hydroxide pocket
  1. Alkoxide ion produced on serine.
  2. N+ of histidine ring
  3. H+ of serine
  4. O- of aspartic acid
  1. Aspartic acid and histidine play important roles.
  2. An electrophilic attack is at the core of the reaction mechanism.
  3. The slow step is the first one.
  4. The alkoxide ion forms on aspartic acid.
  1. It determines the binding/cutting specificity of the enzyme.
  2. It stabilizes an unstable tetrahedral intermediate.
  3. It is the location of the catalytic triad.
  4. It requires serine for binding.

Dozent des Vortrages Serine Proteases – Enzyme Catalysis

 Kevin Ahern, PhD

Kevin Ahern, PhD

Dr. Kevin Ahern is a Professor in the Department of Biochemistry and Biophysics at Oregon State University (OSU), USA.
He obtained his PhD in Biochemistry from Oregon State University. Currently, he teaches courses for health sciences students at OSU.
He is co-author of three Open Educational electronic textbooks on Biochemistry and a Guide to Getting Into Medical School.
Due to his achievements, he earned OSU’s highest teaching recognition, the Elizabeth P. Ritchie Distinguished Professor Award in 2017.
Within Lecturio, Dr. Ahern teaches courses on Biochemistry and on "How to Get into Medical School”.


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Well explained
von Mary T. am 26. Januar 2019 für Serine Proteases – Enzyme Catalysis

Attaractively and well explained video of serine protease catalytic mechanism that I have ever seen...Thank you..????

Thanks a lot prof.
von Ahmad Jawid A. am 30. April 2018 für Serine Proteases – Enzyme Catalysis

It is really helpful. I appreciate your kind efforts. Thanks verh much.

von Amna A. am 26. April 2018 für Serine Proteases – Enzyme Catalysis

He simplified the concepts and illustrated by a very nice way