Serine Proteases – Enzyme Catalysis
Über den Vortrag
Der Vortrag „Serine Proteases – Enzyme Catalysis“ von Kevin Ahern, PhD ist Bestandteil des Kurses „CUSM 5100“.
Quiz zum Vortrag
Why is enzyme catalysis so effective?
- It lowers the energy of activation of a reaction.
- It changes the Gibbs free energy change of a reaction.
- Enzymes have constant, unmodulated activity.
- It allows reactions to go forward.
Which of the following is true of serine proteases?
- They use serine for catalysis in their active sites.
- They cut target proteins at serine residues.
- They bind serine during catalysis.
- They are misnamed because they do not involve serine at all.
The catalytic triad of the serine protease is composed of which of the following?
- Serine, histidine, and aspartic acid
- Serine, glutamic acid, and histidine
- Serine, glycine, and aspartic acid
- Serine, lysine, and histidine
- Serine, alanine, and selenocysteine
Which of the following site allows for the binding of an unstable intermediate during the proteolytic reaction of serine proteases?
- Oxyanion hole
- Active site
- Allosteric site
- S1 pocket
- Hydroxide/alkoxide pocket
Which of the following determines the specificity of the enzyme, serine protease?
- S1 pocket
- Oxyanion hole
- Active site
- Allosteric site
- Alkoxide/hydroxide pocket
Which of the following acts as a nucleophile during the catalytic action of a serine protease enzyme?
- Alkoxide ion produced on serine.
- N+ of histidine ring
- H+ of serine
- O- of aspartic acid
Which of the following is true about the mechanism of action of serine proteases?
- Aspartic acid and histidine play important roles.
- An electrophilic attack is at the core of the reaction mechanism.
- The slow step is the first one.
- The alkoxide ion forms on aspartic acid.
Which of the following is true of the S1 pocket of a serine protease?
- It determines the binding/cutting specificity of the enzyme.
- It stabilizes an unstable tetrahedral intermediate.
- It is the location of the catalytic triad.
- It requires serine for binding.
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Dozent des Vortrages Serine Proteases – Enzyme Catalysis
Kevin Ahern, PhD
Dr. Kevin Ahern is a Professor in the Department of Biochemistry and Biophysics at Oregon State University (OSU), USA.
He obtained his PhD in Biochemistry from Oregon State University. Currently, he teaches courses for health sciences students at OSU.
He is co-author of three Open Educational electronic textbooks on Biochemistry and a Guide to Getting Into Medical School.
Due to his achievements, he earned OSU’s highest teaching recognition, the Elizabeth P. Ritchie Distinguished Professor Award in 2017.
Within Lecturio, Dr. Ahern teaches courses on Biochemistry and on "How to Get into Medical School”.
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Attaractively and well explained video of serine protease catalytic mechanism that I have ever seen...Thank you..????
It is really helpful. I appreciate your kind efforts. Thanks verh much.
He simplified the concepts and illustrated by a very nice way
