Thymidylate Synthase and Recycling of Folates
Über den Vortrag
Der Vortrag „Thymidylate Synthase and Recycling of Folates“ von Kevin Ahern, PhD ist Bestandteil des Kurses „Pyrimidine & Purine Metabolism, Gout (Texas A&M FOM II 2020 Exam Unit 1)“. Der Vortrag ist dabei in folgende Kapitel unterteilt:
- Thymidylate Synthase
- Recycling of Folates
Quiz zum Vortrag
Which of the following is true regarding thymidylate synthase?
- It transfers a carbon from a folate to make dTMP.
- It catalyzes the removal of a methyl group from dUMP to form dTMP.
- It requires 5-fluorouracil to function.
- All of the answers are true.
- None of the answers are true.
Which of the following is true regarding dihydrofolate reductase?
- It is necessary for folate recycling.
- It is inhibited by dihydrofolate.
- It is inhibited by tetrahydrofolate.
- All of the answers are true.
- None of the answers are true.
Which of the following is true regarding methotrexate?
- All of the answers are true.
- It is an inhibitor of dihydrofolate reductase.
- It is used in chemotherapy.
- It resembles dihydrofolate.
Which of the following is not true regarding suicide inhibitor?
- The suicide inhibitor causes the activation of cancer-causing enzymes and leads to the formation of malignant tissues.
- The suicide inhibitor binds to the enzyme by covalent bonding and causes irreversible enzyme inhibition.
- The suicide inhibitor is usually a substrate analog.
- 5-fluorouracil is a suicide inhibitor of the thymidylate synthase enzyme.
- Due to its suicide inhibitor nature, 5-fluorouracil is used in the treatment of cancerous tissues.
Which of the following descriptions is correct?
- 5,10-Methylenetetrahydrofolate - donates a methyl group to convert dUMP to dTMP
- Methotrexate - stimulates cell division by participating in regeneration of 5,10-methylenetetrahydrofolate
- Thymidylate synthase - converts dTMP to dUMP
- 5-fluorouracil - promotes the conversion of dUMP to dTMP
- Serine hydroxymethyltransferase - promotes the conversion of dihydrofolate into tetrahydrofolate
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Dozent des Vortrages Thymidylate Synthase and Recycling of Folates
Kevin Ahern, PhD
Dr. Kevin Ahern is a Professor in the Department of Biochemistry and Biophysics at Oregon State University (OSU), USA.
He obtained his PhD in Biochemistry from Oregon State University. Currently, he teaches courses for health sciences students at OSU.
He is co-author of three Open Educational electronic textbooks on Biochemistry and a Guide to Getting Into Medical School.
Due to his achievements, he earned OSU’s highest teaching recognition, the Elizabeth P. Ritchie Distinguished Professor Award in 2017.
Within Lecturio, Dr. Ahern teaches courses on Biochemistry and on "How to Get into Medical School”.
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