Deoxyribonucleotide Synthesis and Ribonucleotide Reductase
Über den Vortrag
Der Vortrag „Deoxyribonucleotide Synthesis and Ribonucleotide Reductase“ von Kevin Ahern, PhD ist Bestandteil des Kurses „Pyrimidine & Purine Metabolism, Gout (Texas A&M FOM II 2020 Exam Unit 1)“. Der Vortrag ist dabei in folgende Kapitel unterteilt:
- Deoxyribonucleotide Synthesis
- Ribonucleotide Reductase
- RNR Reaction Mechanism
Quiz zum Vortrag
Which of the following is true regarding deoxyribonucleotide de novo synthesis?
- It requires ribonucleotide reductase.
- It starts with ribonucleoside monophosphates.
- It produces dTTP from dCTP.
- Ribonucleotide reductase requires one water molecule to convert from its reduced form to an oxidized form.
- It requires the enzyme ribonucleotide hydroxylase.
Which of the following is true regarding ribonucleotide reductase (RNR)?
- It has allosteric sites on the large subunit.
- It has a small subunit called R1.
- The small subunit has three allosteric sites.
- The large subunit has three allosteric sites.
- The large subunit has a tyrosine which is important in the reaction mechanism.
Which of the following is true regarding the catalysis by ribonucleotide reductase (RNR)?
- It involves the transfer of electrons through sulfhydryls.
- It requires a phenylalanine radical.
- It involves the donation of electrons to the enzyme from the ribonucleotide.
- The reduced form of RNR has a hydroxyl radical that is important for the reaction mechanism.
- The reduction of sulfhydryl is necessary to generate the oxidized form of RNR.
Which of the following assists with the conversion of oxidized ribonucleotide reductase enzyme back into a reduced form?
- Reduced thioredoxin
- Oxidized thioredoxin
- Radicalized tyrosine
- Oxidized tyrosyl radicals
- Reduced tyrosyl radicals
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Dozent des Vortrages Deoxyribonucleotide Synthesis and Ribonucleotide Reductase
Kevin Ahern, PhD
Dr. Kevin Ahern is a Professor in the Department of Biochemistry and Biophysics at Oregon State University (OSU), USA.
He obtained his PhD in Biochemistry from Oregon State University. Currently, he teaches courses for health sciences students at OSU.
He is co-author of three Open Educational electronic textbooks on Biochemistry and a Guide to Getting Into Medical School.
Due to his achievements, he earned OSU’s highest teaching recognition, the Elizabeth P. Ritchie Distinguished Professor Award in 2017.
Within Lecturio, Dr. Ahern teaches courses on Biochemistry and on "How to Get into Medical School”.
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