Pyrimidine de novo Metabolism: OMP Decarboxylase and Synthesis of UTP & CTP von Kevin Ahern, PhD

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Über den Vortrag

Der Vortrag „Pyrimidine de novo Metabolism: OMP Decarboxylase and Synthesis of UTP & CTP“ von Kevin Ahern, PhD ist Bestandteil des Kurses „Purine and Pyrimidine Metabolism“.

Quiz zum Vortrag

  1. The second step is catalyzed by a regulatory enzyme.
  2. Aspartate and bicarbonate are the starting materials.
  3. CMP is the first pyrimidine made.
  4. The ring/pyrimidine base is synthesized after the attachment to a ribose-phosphate.
  5. UMP is the first pyrimidine synthesized.
  1. All of the answers are true.
  2. Two sequential reactions are required.
  3. Two kinases are involved.
  4. Two ATPs are required.
  5. No regulation occurs.
  1. A transamination occurs.
  2. Two ATPs are required.
  3. No regulation occurs.
  4. It is an energy-producing reaction.
  5. It is catalyzed by CTP synthetase.
  1. The OMP decarboxylase enzyme needs ATP as a co-factor to regulate the synthesis of pyrimidines.
  2. Orotidine monophosphate is the first pyrimidine intermediate metabolite that appears during the de novo synthesis of pyrimidines.
  3. The OMP decarboxylase enzyme fastens up the conversion of OMP to UMP 100 quadrillion times faster than an uncatalyzed reaction.
  4. The conversion of UTP to CTP involves a transamination reaction catalyzed by the CTP synthetase enzyme.
  5. The CTP synthetase enzyme is activated by GTP, whereas the CTP inhibits it to maintain the purine to pyrimidine balance in a cell.

Dozent des Vortrages Pyrimidine de novo Metabolism: OMP Decarboxylase and Synthesis of UTP & CTP

 Kevin Ahern, PhD

Kevin Ahern, PhD

Dr. Kevin Ahern is a Professor in the Department of Biochemistry and Biophysics at Oregon State University (OSU), USA.
He obtained his PhD in Biochemistry from Oregon State University. Currently, he teaches courses for health sciences students at OSU.
He is co-author of three Open Educational electronic textbooks on Biochemistry and a Guide to Getting Into Medical School.
Due to his achievements, he earned OSU’s highest teaching recognition, the Elizabeth P. Ritchie Distinguished Professor Award in 2017.
Within Lecturio, Dr. Ahern teaches courses on Biochemistry and on "How to Get into Medical School”.


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von KARMELIA S. am 06. September 2020 für Pyrimidine de novo Metabolism: OMP Decarboxylase and Synthesis of UTP & CTP

First of all, I like the depth of this lecture and Professor Ahern is clearly very knowledgeable and concise on the the topic being discussed. And I also like due to the fact that this video is clearly a high-yield resource which is very helpful for my upcoming medical exam. However, I believe that this could have been better had the previous cycles preceding the formation of OMP explained as well in order for us the students to be able to get the essence of the information better. That's all I have got to say