Catabolism of Guanine & Hypoxanthine and Purine Nucleotide Salvage
Über den Vortrag
Der Vortrag „Catabolism of Guanine & Hypoxanthine and Purine Nucleotide Salvage“ von Kevin Ahern, PhD ist Bestandteil des Kurses „Purine and Pyrimidine Metabolism“. Der Vortrag ist dabei in folgende Kapitel unterteilt:
- Catabolism of Guanine and Hypoxanthie
- Purine Nucleotide Salvage
Quiz zum Vortrag
Which of the following occurs in the catabolism of hypoxanthine?
- Allopurinol inhibits xanthine oxidase.
- Xanthine oxidase catalyzes the conversion of guanine into xanthine.
- Uric acid is formed directly from guanine.
- Guanine is converted to hypoxanthine by guanase.
- Allopurinol inhibits guanase.
Which of the following is true regarding gout?
- It is caused by crystals of uric acid.
- High hypoxanthine concentrations cause gout.
- Gout patients have a higher than average incidence of multiple sclerosis.
- It is worsened by allopurinol.
- It may be cured with a purine-rich diet.
Which of the following is true regarding the salvage synthesis of purine nucleotides?
- It results in Lesch-Nyhan syndrome if HGPRT is absent.
- It includes only the purine bases.
- It requires ribose-5-phosphate as a source of ribose.
- Guanine is unable to participate in this salvage pathway.
- Adenine is unable to participate in this salvage pathway.
Which statement is true regarding Lesch-Nyhan syndrome?
- Lesch-Nyhan syndrome occurs due to a deficiency of hypoxanthine-guanine phosphoribosyltransferase enzyme.
- Lesch-Nyhan syndrome is inherited in an autosomal recessive manner.
- Lesch-Nyhan syndrome has a good prognosis and patients recover by the second decade of life.
- Lesch-Nyhan syndrome is associated with a deficiency of uric acid in all the body fluids for the patient suffering from HPRT gene on the X-chromosome.
- Lesch-Nyhan syndrome is not associated with neurological problems.
Which statement is true regarding allopurinol?
- Allopurinol is used in the treatment of gout because of its ability to inhibit uric acid production.
- Allopurinol is a pyrimidine analog.
- Allopurinol is an activator of the enzyme xanthine oxidase.
- Allopurinol enhances the synthesis of urea from the uric acid by activating the enzyme xanthine oxidase.
- Allopurinol inhibits the salvage of hypoxanthine and xanthine to purine ribotides.
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Dozent des Vortrages Catabolism of Guanine & Hypoxanthine and Purine Nucleotide Salvage
Kevin Ahern, PhD
Dr. Kevin Ahern is a Professor in the Department of Biochemistry and Biophysics at Oregon State University (OSU), USA.
He obtained his PhD in Biochemistry from Oregon State University. Currently, he teaches courses for health sciences students at OSU.
He is co-author of three Open Educational electronic textbooks on Biochemistry and a Guide to Getting Into Medical School.
Due to his achievements, he earned OSU’s highest teaching recognition, the Elizabeth P. Ritchie Distinguished Professor Award in 2017.
Within Lecturio, Dr. Ahern teaches courses on Biochemistry and on "How to Get into Medical School”.
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Amazing way of teaching, compact and efficient. Really good job, keep doing it Mr. Ahern.
Fantastic lecture, just the amount of information I needed to cover and retain the topic.
