Fatty Acid Synthesis
Über den Vortrag
Der Vortrag „Fatty Acid Synthesis“ von Kevin Ahern, PhD ist Bestandteil des Kurses „Lipid Metabolism“.
Quiz zum Vortrag
In peroxisomes, which of the following is preferentially oxidized?
- Long chain fatty acids
- Trans fatty acids
- Cis fatty acids
- Short chain fatty acids
Where does fatty acid synthesis predominantly occur?
- In the cytoplasm.
- In the mitochondrion.
- In peroxisomes.
- In membranes.
Which of the following statements about fatty acid synthesis is NOT true?
- It uses carnitine.
- It uses acyl carrier protein (ACP).
- It uses NADPH.
- It uses a three-carbon intermediate.
Which of the following is true of acetyl-CoA carboxylase?
- It catalyzes the formation of malonyl-CoA.
- It catalyzes an important decarboxylation.
- It requires NAD+.
- It requires FAD.
Acetyl-CoA Carboxylase is activated by which of the following?
- Citrate
- Phosphorylation
- AMP
- Long chain fatty acids
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Dozent des Vortrages Fatty Acid Synthesis
Kevin Ahern, PhD
Dr. Kevin Ahern is a Professor in the Department of Biochemistry and Biophysics at Oregon State University (OSU), USA.
He obtained his PhD in Biochemistry from Oregon State University. Currently, he teaches courses for health sciences students at OSU.
He is co-author of three Open Educational electronic textbooks on Biochemistry and a Guide to Getting Into Medical School.
Due to his achievements, he earned OSU’s highest teaching recognition, the Elizabeth P. Ritchie Distinguished Professor Award in 2017.
Within Lecturio, Dr. Ahern teaches courses on Biochemistry and on "How to Get into Medical School”.
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I've reviewed the Video, and while it provides a comprehensive overview, there are a few points that need clarification. "Fatty acid synthesis doesn't occur in the mitochondrion; it occurs in the cytoplasm, sequestered from fatty acid oxidation, simplifying the regulation of the two pathways." Clarification: Fatty acid synthesis indeed occurs in the cytoplasm, separate from fatty acid oxidation that takes place in mitochondria. This separation allows for streamlined regulation, ensuring the balance between synthesis and breakdown. "Fatty acid synthesis is chemically similar to the reverse of oxidation, involving joining, reduction, loss of water, and a final reduction, making it essentially the reverse of oxidation." Clarification: Fatty acid synthesis does indeed involve joining of acetyl and malonyl units, reduction steps, and removal of water, making it similar but not exactly the reverse of oxidation. The subtle differences in the chemical steps are crucial for the controlled synthesis of fatty acids. "The enzyme acetyl-CoA carboxylase is regulated through phosphorylation by AMP-activated protein kinase and allosteric binding of citrate, ensuring the balance between synthesis and cellular energy levels." Clarification: Acetyl-CoA carboxylase, a key enzyme in fatty acid synthesis, is indeed regulated through phosphorylation and allosteric binding of citrate. This regulation allows cells to respond to energy demands, modulating fatty acid production accordingly. "Fatty acid synthesis involves a series of steps catalyzed by the multifunctional enzyme fatty acid synthase, where individual activities within the enzyme complex work together, ensuring efficient fatty acid production." Clarification: Fatty acid synthase, a multi functional enzyme complex, plays a central role in fatty acid synthesis. Its individual activities work in harmony within the complex, allowing for the sequential addition of carbon units and the creation of fatty acids up to 16 carbons in length.
