Heme Synthesis von Kevin Ahern, PhD

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Über den Vortrag

Der Vortrag „Heme Synthesis“ von Kevin Ahern, PhD ist Bestandteil des Kurses „Amino Acid Metabolism“.


Quiz zum Vortrag

  1. It starts with glycine and succinyl-CoA.
  2. It begins with a cytoplasmic enzyme.
  3. It begins with the incorporation of carbon dioxide.
  4. It begins with acetyl-CoA and glutamate.
  5. The first step is catalyzed by aminolevulinic acid decarboxylase.
  1. Two glycines and two succinyl-CoAs would be required.
  2. A ring structure is destroyed.
  3. The enzyme is actually stimulated by heavy metals.
  4. Its formation requires decarboxylation.
  5. Porphobilinogen synthase is sensitive to cobalt ions.
  1. Ammonia is released during this process.
  2. Six glycines and six succinyl-CoAs would be required.
  3. Increased production results in a type of porphyria.
  4. A ferrous ion is inserted into its center immediately after it is synthesized.
  1. It is the first cyclic intermediate in heme synthesis.
  2. Its synthesis requires addition of water.
  3. It is found in excess in the condition of congenital erythropoietic porphyria.
  4. It is slowly converted to coproporphyrinogen III.
  1. It has the highest rate of catalysis of any known enzyme.
  2. It decarboxylates coproporphyrinogen III.
  3. It is a methodical enzyme, working very slowly.
  4. It requires four carbon dioxide molecules in the reaction it catalyzes.
  1. The enzyme catalyzing its formation is in the mitochondrion.
  2. Two molecules of coproporphyrinogen III are consumed during its synthesis.
  3. The enzyme uses magnesium in catalysis.
  4. 2 molecules of oxygen are produced in the oxidative decarboxylation reaction it catalyzes.
  1. It is formed in a reduction reaction
  2. It is a precursor of heme and chlorophyll.
  3. It is ready to receive a ferrous ion into its center to form heme.
  4. It is formed in a reaction catalyzed by an inner mitochondrial enzyme.
  1. It requires electronic rearrangement for its final form.
  2. Its synthesis can start even if no iron-binding proteins are not present in the mitochondria.
  3. Ferrocatalase is required in the final step of its formation.
  4. It is formed as heme C and other hemes are made from it.

Dozent des Vortrages Heme Synthesis

 Kevin Ahern, PhD

Kevin Ahern, PhD

Dr. Kevin Ahern is a Professor in the Department of Biochemistry and Biophysics at Oregon State University (OSU), USA.
He obtained his PhD in Biochemistry from Oregon State University. Currently, he teaches courses for health sciences students at OSU.
He is co-author of three Open Educational electronic textbooks on Biochemistry and a Guide to Getting Into Medical School.
Due to his achievements, he earned OSU’s highest teaching recognition, the Elizabeth P. Ritchie Distinguished Professor Award in 2017.
Within Lecturio, Dr. Ahern teaches courses on Biochemistry and on "How to Get into Medical School”.


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amazing
von Ahmed F. am 02. April 2019 für Heme Synthesis

it is really amazing lecture & has been organized well thank you

 
After studying Heme, I began to doubt life...
von Jerry J. am 03. April 2018 für Heme Synthesis

Thank you very much! Those extraordinarily awesome questions help me better understand the whole thing with details!