Proofread and Repair Mechanisms
About the Lecture
The lecture Proofread and Repair Mechanisms by Georgina Cornwall, PhD is from the course DNA Repair & Genetic Mutations.
Included Quiz Questions
What is the primary mechanism of DNA proofreading?
- The 3'-5' exonuclease activity of DNA polymerase
- Photolyase activity
- Excision repair
- Resynthesis by DNA polymerase
- Removal and splicing by telomerase
Which of the following statements are CORRECT regarding mutagens? Select all that apply.
- Mutagens cause errors in DNA.
- Ultraviolet (UV) light causes DNA damage as thymine residues form a dimer.
- Ionization radiation, UV light, reactive oxygen species, polycyclic aromatic hydrocarbons, and transposons are known to cause DNA mutations.
- Mutagens help the enzyme photolyase chop off damaged nucleotide sequences in dsDNA.
- During DNA replication, the mutagen gets associated with DNA polymerase and helps recognize wrongly incorporated nitrogenous bases.
Which of the following is TRUE of photolyase?
- It is a visible light–dependent DNA-repair enzyme specific for UV light–damaged DNA repair.
- It depends on the presence of mutagen molecules to repair damaged DNA.
- It works in association with transposons to repair damaged DNA.
- It creates thymine dimers in the DNA helix to stop the transposition of transposons in a gene.
- It gets activated in the presence of UV light and chops off the transposon DNA from the damaged gene.
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Author of lecture Proofread and Repair Mechanisms
Georgina Cornwall, PhD
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Helpful!
By M.Baran Y. on 21. November 2017 for Proofread and Repair Mechanisms
Very helpful on understanding the basics of the repair mechanisms.
Quiz Overview
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