00:01
Welcome.
00:02
With this talk, we're going to cover
all of the viral hepatitis entities
that you need to be concerned
with in the human population.
00:09
So all the way from
viral hepatitis A to E.
00:14
As the name indicates,
viral hepatitis is inflammation of
the liver due to viral infections.
00:22
Looking at the epidemiology,
we're going to kind of
run through each of these,
I'll give you a broad
overview in the next slide.
00:28
And then we'll go
through A, B, C, D, E.
00:32
So all of the viral
infections in the liver
have various modes
of transmission,
and we'll cover
these each in turn.
00:41
They can vary from completely
asymptomatic infections
to fulminant liver failure.
00:48
The pathology is really
important to understand
because it's secondary
to the immune response.
00:52
It's not, in most cases,
the virus killing hepatocytes.
00:57
But it's the normal
immune system
responding to virally
infected hepatocytes
and that's what
causes the damage.
01:05
So 90% of mortality
occurs due to
hepatitis B, and C.
01:11
A, we're gonna see in a moment,
it is really fairly benign.
01:14
And it's very unusual for that to
cause any significant pathology.
01:18
Similarly, D requires
B, as we'll see,
it is not a major
source of mortality
and E is really kind
of a minor entity
unless you're pregnant
or immunocompromised.
01:29
So most of the disease
that we're gonna see
from viral hepatitis B, or C.
01:35
It's important to
understand too that
even as the disease is caused
by the immune response,
if you don't have
an immune response,
you and the virus can live
happily ever after together,
in matrimony.
01:50
So patients can be
chronic carriers of virus
if they don't elicit
an immune response.
01:56
When there is inflammation,
when there is ongoing
hepatocyte damage,
all of these can
progress to cirrhosis,
and also there's increased risk
for hepatocellular carcinoma.