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Now we're going to talk about depression, one of the most common mood disorders that's
extremely important to know about for your exam. So what is depression? Well, it's an
episode of dysphoria that's associated with more than a low mood, but also associated with
a loss of interest in activities. The epidemiology for depression includes a lifetime prevalence
of 12%. The onset can be at any age, however, young adults and elderly are at particular
risk. The prevalence in 18 to 29-year-old individuals is actually threefold higher than in other
groups. Females will experience nearly threefold higher rates of depression than man and
there is actually no ethnic or socioeconomic difference. However, a very important note to
keep in mind is that while depression can occur across ethnicities, many minorities are
actually more likely to be misdiagnosed and instead of being accurately diagnosed with
depression or mood disorder, they may be labeled as having schizophrenia, an important
note to consider. About 2/3 of all depressed patients will contemplate suicide and 10-15%
actually died by suicide. Only half of the patients with major depressive disorder will ever
receive treatment. So most people go completely unnoticed. Do you know who described
depression as anger turned inwards? That was Sigmund Freud. He actually wrote about this
concept in his 1917 paper called Mourning and Melancholia. Here he described depression as
introjected rage over object loss. Let me give you a clinical case example. Consider a
40-year-old woman. She has been struggling with feeling unloved at home, dissatisfied in her
career and taken advantage of by her extended family. She has had longstanding troubles with
her sleep, appetite, sense of self-worth, energy and she has lost interest in all of her hobbies.
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When she learns that her husband has been secretly taking money from her personal account,
this woman becomes enraged and furious at her husband. But then, she takes her own life.
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A perfect example of anger turned inwards. The cause of depression is not exactly known, but
we do believe that biological, genetic, environmental, and psychosocial factors play a role.
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Let's consider this chart here. There's a lot of information. This all describes the pathogenesis
of depression. So what is decreased in patients with depression? Well, we know that drugs
that increase the availability of serotonin, noradrenaline, and dopamine will actually alleviate
symptoms of depression. And therefore we think that all of these neurotransmitters are
reduced in people who have depression. Let's talk a little bit about the monoamine hypothesis.
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This postulates that antidepressants increase the amount of noradrenaline or norepinephrine
and serotonin in the brain primarily by increasing the concentration of these
neurotransmitters in the synapse and by downregulation of their postsynaptic receptors.
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Another question to post to you is what neurotransmitter is decreased in the cerebrospinal
fluid in patients with depression? That answer is serotonin. When it comes to neuroendocrine
abnormalities, what 2 main factors in this category do you know about that are associated
with depression? The answer is high cortisol and this is from hyperactivity of the hypothalamic
pituitary adrenal access, also thyroid disorders, very important to know are associated with
major depression. There are also psychosocial factors, but before we get to those let's talk a
little bit more about what the hippocampus has to do with cortisol. Well, it tends to be
especially sensitive to the neurotoxic properties of cortisol which is actually elevated during
times of stress. The hippocampal volume may actually be correlated to a depressed episode
so we know with increased stress comes higher cortisol levels and then depression and
changes to the hippocampus. Now, how can family affect to developing depression? Well, a few
things. Loss of a parent before the age of 11 can be associated with depression. But a stable
family and stable psychosocial functioning such as good attachments to early caregivers,
support network of family and friends are all really good prognostic factors. Genetics also play
a role in developing depression. We tend to think that depression can be inherited and pass
along in the generations. Usually, if somebody's presenting with depression, it's going to be
likely that someone in their family also has had depression. First degree relatives are 2-3
times more likely to have major depression.