00:00
Let's shift gears and talk a little bit about Mycoplasma Pneumonia and I think this is a confusing
area and an area where the evidence in pediatrics is only just starting to getting generated
and it's maybe showing that this isn't as big a problem as we might have suspect it. First, you
will have heard children under 5 don't get Mycoplasma. That's not true. They do but at a lower
rate and there have been outbreaks where they get them at the same rate. So, it really depends
on what's going on. Next, you may have heard that Mycoplasma pneumonia causes walking pneumonia.
00:36
So if they're walking around that's probably Mycoplasma. Okay, yes, but it also causes, for example,
asthma exacerbations where there is no pneumonia at all or it can cause a lobar pneumonia. So you
really don't know what's a Mycoplasma pneumonia and what's not based on history. Next, you may
have heard that Mycoplasma pneumonia has a typical diffuse patterned x-ray appearance. Simply
not true. Can look any way at once, in fact in 1 study 10% of pneumonias with <i>Mycoplasma</i> had
an effusion. Next, there's a myth and I am saying this that it responds to azithromycin. We
have no evidence that Mycoplasma pneumonia gets better with azithromycin in children. It may
well be that it gets better because of anti-inflammatory properties of azithromycin. So it's
unclear that even treating <i>Mycoplasma</i> makes a difference. The reality is <i>Mycoplasma</i> largely gets
better on its own. It follows up having more typical of viral illness. It's less likely to actually
need antimicrobials. <i>Mycoplasma</i>, if you do wish to test it, is best tested in most centers by
simply checking for a rise in titers but the problem is you need a second set of titers, something
like 6 weeks later. So what's the point in making a diagnosis 6 weeks after you've already treated
the illness? There is a rapid viral PCR that is available and it seems to roughly correlate with
the disease so if you have that you could certainly get it. But the typical clinical picture of
<i>Mycoplasma</i> is largely unproven and most children have viruses and get better while on azithromycin
because the viruses got better and kids who aren't treated probably get better on its own so
it's not clear that <i>Mycoplasma</i> is as big a deal as we think it is and you probably can miss the
diagnosis just fine. Azithromycin, you generally will treat for a 5-day course. Azithromycin is
not effective against other bacterial causes. So if you think this might be <i>Pneumococcus</i> you'd
be wiser to treat the <i>Pneumococcus</i> than the <i>Mycoplasma</i>. It's unclear who we should treat and
who we should not treat and whether azithro even affects the course of illness. It does kill
bacteria in vitro but in vivo the infection seems to be more of a post infectious inflammatory
condition in many settings of <i>Mycoplasma</i> especially ADEM and other diseases that happen after
the disease. The lung disease, it may be beneficial or not and there actually is some evidence
that maybe steroids would be effective for Mycoplasma pneumonia. That really hasn't been a study,
I wouldn't recommend it but keep in mind that might be on the horizon.