Binding Motifs
About the Lecture
The lecture Binding Motifs by Georgina Cornwall, PhD is from the course Gene Regulation.
Included Quiz Questions
How do regulatory proteins identify specific sequences on the DNA double helix without unwinding the helix?
- By inserting DNA-binding motifs into the major groove of the double helix where the edges of the nitrogen bases protrude
- By inserting RNA polymerase into the major groove of the double helix where the edges of the nitrogen bases protrude
- By inserting DNA-binding motifs into the minor groove of the double helix where the edges of the nitrogen bases protrude
- By inserting RNA promoters into either the major groove or the minor groove of the double helix where the edges of the nitrogen bases protrude
- By inserting operon motifs into the major groove of the double helix where the edges of the nitrogen bases protrude
Which of the following are DNA-binding motifs that regulate DNA expression? Select all that apply.
- Zinc finger motif
- Helix-turn-helix motif
- Leucine zipper motif
- Greek key motif
- Cysteine-leucine-cysteine motif
Which of the following descriptors are paired incorrectly?
- Zinc finger motif – coordination of zinc absorption
- Leucine zipper – two α-helices attached to a hydrophobic portion with many leucines
- Helix-turn-helix motif – two perpendicular α-helical segments
- Zinc finger motif – coordination of zinc ions to bind with DNA
- Homeodomain – plays a major role in several developmental processes of eukaryotes
Which of the following describes a function of homeodomain proteins?
- They regulate the expression of other genes in the development and differentiation of eukaryotes.
- They regulate the expression of DNA replication–regulating genes in eukaryotes.
- They regulate the expression of DNA repair–regulating genes in eukaryotes.
- They regulate the expression of cell cycle–regulating genes in eukaryotes.
- They regulate the expression of cell death–regulating genes in eukaryotes.
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Author of lecture Binding Motifs
Georgina Cornwall, PhD
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This explanation was not clear at all. I had to research a lot of information elsewhere to understand the concepts presented. This is the exact opposite of what is to be expected of something that should make students life easier.
The concepts mentioned in this lecture are very confusing and poorly explained. She made no effort to clarify the meaning of homeodomain, homeoprotein, and other such concepts. Also, she seems very unsure of what she is teaching and the speed is too fast to properly retain the information.
Lesson was so fast and not understandable .Lecturer should have gone from easy points to harder points.She could not make it easier this topic for me .She did not use her hand at all during the lesson.This is so lazy way for giving a lesson and unproffesional.
