Normal Hemostasis: Summary

00:00 So, to summarize and this has been a lot of material, you may want to watch it again, but to summarize. Platelets, so for normal hemostasis, platelets form a platelet plug at the site of injury and again they are binding to newly exposed molecules such as Von Willebrand factor that had been synthesized and are sitting in that matrix ready to go. We have coagulation factors that assemble on the phospholipid surface of activated platelets that's to form the fibrin clot. Okay, so we cement the platelets in place. Even if we're doing all of that, we are also breaking down the clot. So that when the vessel is healed, we do not have something that is a big thrombus. So it's we form it and we take it away. And natural anticoagulants, as described on this slide and we talked about in detail, help keep the clot limited to just the injured site. So it's a nice and very complex and very interesting interplay of pro and anticoagulation with lots of details, but in this last 2 slides we've kind of given you a broad framework to think about that. And with that, we are done with hemostasis thrombosis.