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Postganglionic Sympathetic Nerve Terminal Blockers and Monoamine Oxidase Inhibitors – Drugs in Hypertension
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Slides Hypertension CardiovascularPharm.pdf
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Download Lecture Overview
00:01 Monoamine oxidase inhibitors actually do have some blood pressure activity. 00:07 Remember that MAOs cause a false transmitter. 00:11 They do cause lowering of blood pressure. 00:14 In fact, even in patients who are using monoamine oxidase inhibitors for depression will have a reduction in blood pressure. 00:23 In fact, if you take a look at your psychiatric medication lecture, and today's lecture, you'll see that I stole this image from the psychiatry lecture. 00:33 Now, one of the things I mentioned to you before in the psychiatry lecture is Foods high in tyramine like cheese and wine can cause a release of a large amount of noradrenaline, or norepinephrine. 00:46 And this can cause a large increase in blood pressure. 00:49 Have a look at that other lecture in antidepressants, and you can see how that works. 00:56 Now, these drugs have frequent side effects, they're not very effective and as I said before, they're not used a lot. 01:02 Once again, doctors hate these drugs for hypertension and never think about it. 01:07 but pharmacologist love these drugs and put them on exams in the hypertension section. 01:12 I'm not going to say that about its use in depression because in depression, we do use them more than we do in hypertension.
About the Lecture
The lecture Postganglionic Sympathetic Nerve Terminal Blockers and Monoamine Oxidase Inhibitors – Drugs in Hypertension by Pravin Shukle, MD is from the course Cardiovascular Pharmacology. It contains the following chapters:
- Postganglionic Sympathetic Nerve Terminal Blockers
- Monoamine Oxidase Inhibitors
Included Quiz Questions
Why should patients on MAOIs not eat cheese or drink wine?
- Because tyramine in those products is not broken down by MAO, so tyramine can displace NE in synaptic vesicles and cause hypertension
- Because the high calcium content in cheese and alcohol in wine can inhibit the absorption of MAOIs, reducing their effectiveness in treating depression
- Because the fermentation process in cheese and wine produces a compound that directly competes with MAOIs for receptor sites in the brain, leading to reduced cognitive function
- Because cheese and wine increase the body's production of MAO, leading to a rapid breakdown of neurotransmitters like serotonin and dopamine, which can worsen depression symptoms E. Because the sulfites used as preservatives in wine and certain cheeses can cause an allergic reaction that is amplified by the presence of MAOIs in the system, leading
- Because the sulfites used as preservatives in wine and certain cheeses can cause an allergic reaction that is amplified by the presence of MAOIs in the system, leading to severe respiratory distress
Which statement regarding monoamine oxidase inhibitors is most accurate?
- They prevent the breakdown of monoamine neurotransmitters.
- They prevent the reuptake of monoamine neurotransmitters.
- They increase the reuptake of monoamine neurotransmitters.
- They deplete the nerve terminal of monoamine neurotransmitters.
- They prevent the release of monoamine neurotransmitters.
Author of lecture Postganglionic Sympathetic Nerve Terminal Blockers and Monoamine Oxidase Inhibitors – Drugs in Hypertension
Pravin Shukle, MD
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