00:01
Hello there.
00:02
In this talk, we're going to
cover a very common entity
within the normal breast
called fibrocystic change.
00:09
Back in the day, we used to
call this fibrocystic disease,
but it's not a disease, it is the normal
proliferation regression of breast tissue.
00:18
And sometimes things
don't regress completely.
00:21
And we develop these
fibrous, cystic changes.
00:23
Let's talk about that.
00:25
So, during normal
menstrual cycles,
there's recurrent bouts or
cycles of epithelial proliferation.
00:33
And then, as you have reduced estrogen levels,
there's regression of that proliferative epithelium,
well, sometimes it doesn't always
go back completely to ground zero.
00:44
So there will be over time accumulation
of some epithelial proliferation,
there may be an accumulation
due to secondary ductal obstruction
of inflammation
and fibrous tissue.
00:56
And with obstruction,
you make get cyst formation.
00:59
So this is just what happens pretty much
in every breast over childbearing years.
01:06
The epidemiology.
01:08
It's reported in 60 to 75% of women,
but if we did a very careful evaluation,
it would probably be more
like 90 to 95% of women.
01:17
Again, typically develops
during the childbearing years.
01:20
The pathophysiology is
as I've already indicated.
01:24
Every cycle you have estrogen
driven connective tissue
and epithelial proliferation.
01:29
And then with the
estrogen waning
during the end of the menstrual
cycle, you have regression.
01:35
However, you may not
have complete regression.
01:40
So, dilation and obstruction
of ducts may occur
because of epithelium that
gets into the draining areas.
01:51
With obstruction, you may
actually have cyst formation
and then rupturing of those cysts within
with continued accumulation of material
with rupturing of the cysts that
will cause chronic inflammation.
02:03
With inflammation
comes stromal fibrosis.
02:06
You do this over and over and
over again from ages 15 to 50.
02:11
And you accumulate
fibrocystic change.
02:15
The clinical presentation?
Pretty much is what
you would expect.
02:19
So the breast will feel firmer
as a result of the fibrosis,
there may be
palpable breast lumps.
02:25
They're usually multifocal.
02:28
They're usually discrete and mobile,
but these are the dilated cystic structures.
02:33
The changes can change, can fluctuate
throughout the entire menstrual cycle.
02:38
So, these fibrocystic
changes may come and go
and what is present in one cycle may
not necessarily be present the next cycle.
02:48
There may be cyclic breast pain.
02:50
Again, as with the proliferation and
then potentially epithelial sloughing,
and duct obstruction, you may get at
the end of a menstrual cycle, more pain.
03:00
And the findings
are tend to be similar,
not identical clearly, but
similar in both breasts.
03:06
Making the diagnosis.
03:07
So mammography will so typically give you
the appearance of multiple cystic structures
with associated fibrosis.
03:15
Ultrasound can show very
similar changes overall.
03:19
And we will do a biopsy
of these changes to make sure
that there is not malignant potential.
03:25
So though the changes
are quite common,
depending on the
proliferation of the epithelium,
and the way that
that epithelium looks,
there are different risk stratification in
terms of potential developing cancer.
03:38
So we definitely do want to do biopsy
if there's substantial fibrocystic change.
03:44
If it is non
proliferative on biopsy.
03:48
So, this is generally just an
increased kind of cystic structures
without much
proliferation overall,
you may have some
apocrine change.
04:00
These are not associated with
any increased risk of breast cancer.
04:05
If there's proliferation of the epithelium,
but all the cells look pretty normal,
there's no atypia and
again, as a medical student,
you don't have to worry about deciding
whether something is a typical or not.
04:17
That's what's the
pathologist does.
04:19
And when you become
pathologist, and hopefully you all will,
then you will learn how
to make those distinctions.
04:25
But for you, as a medical
student, you as a treating physician,
you'll read your pathology
report, and if they say
they're proliferative breast
disease, but no atypia,
and you can see the different
kinds of entities in there,
then there are others
that increases the risk,
mildly, modestly, up to two
fold of developing breast cancer.
04:47
And then if there's proliferative
breast disease with atypical features,
the cells look a little funky.
04:53
Actually, it happens in about
five to 20% of breast biopsies
that increases the risk up to
fourfold of malignancy.
05:01
And so we want to more
closely follow those patients.
05:05
So you do want to, not just
ignore fibrocystic change,
you want to
appropriately work it up.
05:11
So you can risk
stratify your patients.
05:14
How are you going to treat them?
Well, it depends on
what you saw on biopsy.
05:17
So on nonproliferative, disease observation
and pain management, if there is pain
is all you have to do.
05:24
You may want to put your
patient on oral contraception
to reduce the
cycling of estrogen,
and that may in many cases, reduce
the kind of overall severity of symptoms.
05:36
You can also give androgens
or tamoxifen, aspirate cysts.
05:41
There are other things you can do if the
if the lesions are particularly symptomatic.
05:46
If on biopsy we're seeing
proliferative disease without atypia
that merits then a regular breast
exam and screening mammography
probably every one to two
years, if not more frequently.
05:56
And if there is atypia,
you definitely want to cut out things
that can be identified on mammogram
as being the abnormal areas to
make sure there isn't malignancy
in a little corner
of that atypia.
06:08
You also want to increase the frequency
of breast exams to every six to 12 months,
and certainly with an
annual mammogram.
06:15
In those patients where you already have some
atypia associated with proliferative disease.
06:19
Avoid hormone replacement
therapy and oral contraception.
06:24
With that we've covered fiber
cystic change, very common entity.