00:02
The clinical features of encephalitis are quite variable,
some serious, others less serious.
00:11
Generally, what you see is some sign of infection,
plus ome sign of central nervous system dysfunction.
00:18
The classic features would be fever, headache
and altered mental status.
00:24
Because the brainstem is involved,
particularly the hypothalamus,
there's maybe loss of temperature regulation,
high or low temperature.
00:37
And personality changes,
particularly common at the frontal lobes,
are involved, and that's most
mmon with herpes simplex virus.
00:49
You may or may not have
focal neurologic signs,
like hemiparesis,
aphasia,
ataxia,
cranial neuropathy or mild clonus.
01:04
Seizures may occur.
01:07
And with certain viruses,
the signs of parkinsonism are more common,
particularly West Nile virus,
St. Louis virus
and Japanese encephalitis virus.
01:19
So, they may present with or leave
the patient with Parkinson's.
01:25
Trying to determine the cause may be difficult.
01:29
There may be seasonal clues.
01:31
For example, if it occurs in the summer or
early fall, we’re thinking of arboviruses.
01:39
If it's late fall and winter,
when the insects are not out,
we would think –
and people are indoors, we would think
of the lymphocytic choriomeningitis virus,
particularly in households
that have rats and mice.
01:57
There are some geographic clues
and I've always had trouble remembering these
There are some geographic clues
and I've always had trouble remembering these
and you probably will too
or have if you've studied this.
02:07
There are certain viruses that seem to come from Africa
and covered the entire United States
and that is West Nile virus.
02:19
And then there is St. Louis encephalitis virus.
02:24
That seems to cover the entire United States.
02:26
So, the way I would remember it is,
you've come a long way from St. Louis.
02:31
You've covered the entire United States.
02:35
The one that seems to behave
and involve the eastern seaboard
is eastern equine encephalitis.
02:42
It covers the eastern seaboard
and the Great Lake states.
02:48
This one is totally counterintuitive.
02:53
California encephalitis virus?
That should be out in California, shouldn't it?
Well, no, it turns out to be most common
in the east of the Mississippi River.
03:04
Go figure!
There may be some clues on physical examination
that will lead you to a diagnosis,
such as a rash.
03:15
If the patient has something
resembling chickenpox or has zoster,
you would think of the varicella zoster virus.
03:24
West Nile virus is frequently associated with a rash.
03:28
Enteroviruses commonly are associated with a rash.
03:33
HIV, measles virus, rubella virus,
those are clues that the
encephalitis is due to one of those.
03:41
If a patient presents with keratitis,
orchitis or oophoritis,
we would think of mumps,
but not usually in developed countries where
we have the measles mumps and rubella vaccine.
03:58
If a patient has encephalitis and oral ulcers,
to the top of the list comes herpes simplex
and the enteroviruses.
04:09
caused by one the Coxsackieviruses.