Deep vein thrombosis (DVT) is a blood clot in the deep veins, usually in the lower extremities (though they can occur in the upper extremities, mesenteric, and cerebral veins as well). The affected veins commonly include the popliteal, femoral, iliac, and pelvic veins. The 3 primary factors (known as the Virchow triad) that contribute to DVT formation include: venous stasis, hypercoagulability, and vascular endothelial damage. Any condition that worsens 1 (or more) of these 3 factors increases the risk of DVT formation. Individuals can present with unilateral extremity pain, swelling, and/or redness around the DVT; however, a majority of cases are asymptomatic. Ultrasound can visualize the thrombus. Anticoagulation is the primary mode of treatment; the main objective is preventing a pulmonary embolism (PE).