00:01
We're now going to continue
looking at what happens
after acute inflammation.
00:06
So remember,
we have a sequence of events
from injury, and tissue destruction,
necrosis.
00:13
And then we have
acute inflammatory infiltrates,
neutrophils and vascular changes.
00:19
And now we're going to progress
on to the healing response.
00:21
We're going to clean up
the final mess.
00:24
And we're going to start healing.
00:25
And in order to do that,
we need to tune down
all of the things that happened
during acute inflammation.
00:33
That's what this
particular topic is all about.
00:36
Here's the roadmap
for where we're going to go
in subsequent topic discussions.
00:42
As we get into more and more
of the healing response.
00:45
So initially, we're going to
moderate acute inflammation.
00:48
And then we're going to recruit
macrophages
and we'll talk about that process.
00:53
If everything goes
according to plan,
we regenerate the parenchyma.
We make it whole.
00:59
In the event that we can't,
we may have to then build scar,
and that starts with
new blood vessels or angiogenesis.
01:08
That is a railroad track
for bringing in fibroblasts,
who that will proliferate
and lay down new matrix.
01:15
So we'll deposit
and then remodel that matrix.
01:18
And then finally, we'll wind up
with the complications of healing.
01:22
So that's the roadmap.
01:24
We're gonna now focus right now
on tuning down
the acute inflammatory response.
01:31
Here's where we are
on our sequential peeks
of things going on
during chronic inflammation repair.
01:37
And again, remember that
we're time starts over there
on the left hand side,
we have an
initial vascular response,
that's going to be edema,
increased vascular permeability,
increased vascular flow,
and then we're going to have a peak
of acute inflammation,
which is going to be
the neutrophils.
01:59
Even in the middle of that peak,
that's when we start
turning off the neutrophils
and starting to recruit
the macrophages.
02:08
Eventually, we'll go on
to granulation tissue,
that's the angiogenesis piece,
and then scar and regeneration.
02:14
Okay, so that green arrow
is where we are
on the next few slides.