00:02
So now that we're done
with the conducting zone,
let's move into the
respiratory zone.
00:08
The respiratory zone begins
where the terminal bronchioles
now feed into what are referred
to as respiratory bronchioles.
00:16
These bronchioles will then
lead into our alveolar ducts
and finally into
the alveolar sacs.
00:25
So the respiratory
zone structures include
the alveolar sacs,
which are going to contain
multiple clusters of alveoli.
00:34
And in the lungs,
we have millions like hundreds
of millions of alveoli.
00:42
The alveoli are the actual
site of gas exchange.
00:48
So when it comes to gas exchange
we need to exchange gas
that is in the alveoli
into the blood and conversely
gases that are in the blood
out into the alveoli.
01:00
This happens across
what is known as the
respiratory membrane.
01:05
So the blood air barrier
that consist of the alveolar
and capillary walls
as well as the
basement membranes
of each is very thin
and allows for this gas
exchange by simple diffusion.
01:19
So all of these structures
together these four layers
you have the
alveolar, cell wall,
the basement membrane
of the alveoli,
the basement membrane
of the capillary
and then the endothelium
of the capillary walls,
all four of those
structures make up
this respiratory membrane.
01:38
The alveolar walls are
going to be a single layer
of simple squamous epithelia,
which are going to be made
up of type 1 alveolar cells.
01:48
These are the cells that
are going to take part
in the respiratory exchange
are the gas exchange.
01:55
Also scattered throughout
the alveoli wall.
01:58
You have cuboidal
type 2 alveolar cells.
02:03
These are going to
secrete our alveolar fluid
which is going to keep
the cells and the air
in the alveoli moist
as well as surfactant,
which is very important for
reducing the surface tension
of the alveolar fluid.
02:17
And also here we have
antimicrobial proteins as well.
02:25
So other significant features
of the alveoli include
that they are surrounded
by fine elastic fibers
and the pulmonary capillaries.
02:36
Also, the alveoli are able
to be connected to each other
or connect it to
adjacent alveoli
by way of structures
known as alveolar pores.
02:47
These pores help
to equalize the air pressure
throughout the entire lung
and also can provide
alternate routes for air
and the case of blockages.
02:59
Also in the alveoli,
we have alveolar macrophages
and these are what are there to
keep the alveolar surface sterile.
03:08
And throughout the day,
you have millions
of dead macrophages
found in the alveolar area
that are eventually
swept away by cilia
and then swallowed down
into our esophagus.
03:22
In this image,
I want you to pay close
attention to the close
intimate relationship
between the alveoli
and the alveolar sacs
and the pulmonary capillaries.
03:36
Also in this trend
section of an alveolus
you can also see how
intimate the alveoli
and the blood capillaries are
and also how thin the
respiratory membrane is.
03:49
Remember this thin respiratory
membrane is essential
for efficient gas exchange
into and out of the blood.