00:00
Hi, welcome to our video series on antidepressants.
00:04
Now in this one, we're gonna specifically look at selective serotonin reuptake inhibitors.
00:11
Ready? Alright, here we go.
00:14
Now, SSRIs increase the circulating serotonin in the synapses
by blocking the reuptake of serotonin in the neuron.
00:23
Really? So what? Alright, let's break that down.
00:27
Okay, do we want more circulating serotonin? Yes. Here's why.
00:33
Serotonin is a neurotransmitter, right? That's a messenger.
00:38
So serotonin is a neurotransmitter believed to help regulate -- ready for this list?
Your mood, social behavior, appetite, digestion, sleep, memory, sexual desire, and function. Okay?
That's a really long list. So make sure you kinda take some notes on that.
01:01
We're talking about mood, number one, and social behavior.
01:04
Those are really the things we're after. But it also can impact appetite and digestion.
01:10
Hey, these guys are known to kind of cause weight gain.
01:13
Now, it can mess with your sleep, sometimes it can keep you up.
01:17
It messes with your memory sometimes.
01:20
It impacts your memory, sexual desire and function.
01:24
So these are great in helping certain patients feel better
but they can have a series of side effects that may make someone hesitant to continue taking the medication.
01:34
So first of all, let's lay the groundwork.
01:37
SSRIs increase circulating serotonin in the synapses
because they block it from being reuptaken into the neuron
so instead of having a serotonin up in the neuron, it's still out on those synapses,
that's a good thing. We want more of that available.
01:55
See, the theory is that serotonin, if there's not enough of it available in those synapses,
is linked to a sad or depressed mood.
02:05
Let me give you some examples.
02:07
Now in this one, we did make an exception,
we normally don't put the trademark name in there
but I was pretty sure you've seen some of these names before or heard of them
so that's why we included them.
02:18
But on the NCLEX exam, the only words that will be there are the generic.
02:22
So the first one, paroxetine, that's Paxil.
02:25
You won't see Paxil because that's a trade name in the parenthesis on the NCLEX.
02:30
You'll see the generic name, paroxetine.
02:33
So let's -- let me give you 5 or so more examples.
02:36
Citalopram, otherwise known as Celexa, that's the trade name.
02:40
Fluoxetine, an old friend Prozac. That one has been around forever.
02:45
It's a really cheap script but it's very effective for certain patients.
02:50
Now the other three, we've got Zoloft, Luvox, and Lexapro.
02:55
Okay, now those are the names that you won't see on the test so make sure you look at the generic names.
03:01
I'd recommend pausing, spending a couple minutes here,
just kinda practicing making sure that you know these names.
03:12
Okay, now that you've practiced the names, let's go on.
03:16
So what can we use SSRIs for?
Well, since it's an antidepressant, the first one seems kinda obvious, doesn't it?
They would use it for depression.
03:28
But they're also pretty good for OCD, some of the things of obsessive-compulsive disorder.
03:34
Also social anxiety, post-traumatic stress syndrome, and panic disorder.
03:40
Now, these are different than depression but they often go hand in hand with depression.
03:45
So this particular group of antidepressants, SSRIs, can be really good in treating these other disorders.
03:53
Now here's your job. Figure out a way you wanna kinda group those together.
03:57
Chunk that information to say what other uses can we use SSRIs for besides depression.
04:04
Now, it can also be helpful in eating disorders, premenstrual dysphoric disorder.
04:11
Now, that is -- premenstrual dysphoric disorder comes in synchrony with your menstrual period.
04:17
So obviously, this is a disorder that we treat in women and it comes right around
with perfect timing with your menstrual period so we know that this is what this is.
04:27
You have pretty intense feelings of sadness and depression but it's a couple weeks a month.
04:33
So you can work with your health care provider, with your OB-GYN,
and come up with a treatment with SSRIs is usually pretty effective rather quickly.
04:41
Now also we've got enuresis.
04:43
That's kind of an odd one for you to remember but that's also helpful.
04:47
Remember when something seems so different than the other things, it's easier to remember.
04:53
So take a little time here, hang out, see if you can refresh and review this information
to make sure you have it solid before we go on to the next section.