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Welcome to Pharmacology by Lecturio.
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I'm Dr. Pravine Shukle.
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We're going to be covering some reproductive pharmacology today.
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Listen, this is a huge topic.
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You can see all the different subtypes
and categories on the screen beside me.
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The gonadal hormone antagonists and agonists
sometimes do the same thing
and sometimes they do the opposite thing of what you expect.
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We're going to spend a lot of time in each section
and we're going to go over them in detail,
so that you understand them
and you feel confident answering questions on exams.
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We're going to be talking about estrogens and anti-estrogens.
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We’ll be talking about progestins and anti-progestins
and we're going to be talking about
androgens and anti-androgens.
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With respect to the anti-estrogen medications,
there's a whole bunch of subtypes there.
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There are the receptor antagonists.
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There are aromatase inhibitors
and then there are GnRH agonists, like danazol,
and antagonists, which interestingly enough do the same thing.
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Underneath the receptor antagonist section –
this is estrogen receptor antagonists –
we have full antagonists and we have selective antagonists.
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With respect to the progestins,
we have actual progestin that we administer
and we have an anti-progestin called mifepristone.
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With respect to the androgens,
we have a whole list of medications.
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We have anti-androgens that are receptor antagonists.
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We have 5-α-reductase inhibitors.
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We have synthesis inhibitors.
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And we have other ones such as the GnRH agonists and antagonists.
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When we take a look at reproductive pharmacology,
just have a look at this diagram.
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I won't go over it in detail now
because each section of this diagram
will be placed beside the specific area that we’re talking about.
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This just gives us an overview.
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So, have a look at it on your own time.
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It's a very good diagram to understand how all of the drugs fit in.