PUMS - MD Biochemistry II

To the point. Good organized pathway explanations. Pedagogical presentation skills.

I've reviewed the Video, and while it provides a comprehensive overview, there are a few points that need clarification. "Fatty acid synthesis doesn't occur in the mitochondrion; it occurs in the cytoplasm, sequestered from fatty acid oxidation, simplifying the regulation of the two pathways." Clarification: Fatty acid synthesis indeed occurs in the cytoplasm, separate from fatty acid oxidation that takes place in mitochondria. This separation allows for streamlined regulation, ensuring the balance between synthesis and breakdown. "Fatty acid synthesis is chemically similar to the reverse of oxidation, involving joining, reduction, loss of water, and a final reduction, making it essentially the reverse of oxidation." Clarification: Fatty acid synthesis does indeed involve joining of acetyl and malonyl units, reduction steps, and removal of water, making it similar but not exactly the reverse of oxidation. The subtle differences in the chemical steps are crucial for the controlled synthesis of fatty acids. "The enzyme acetyl-CoA carboxylase is regulated through phosphorylation by AMP-activated protein kinase and allosteric binding of citrate, ensuring the balance between synthesis and cellular energy levels." Clarification: Acetyl-CoA carboxylase, a key enzyme in fatty acid synthesis, is indeed regulated through phosphorylation and allosteric binding of citrate. This regulation allows cells to respond to energy demands, modulating fatty acid production accordingly. "Fatty acid synthesis involves a series of steps catalyzed by the multifunctional enzyme fatty acid synthase, where individual activities within the enzyme complex work together, ensuring efficient fatty acid production." Clarification: Fatty acid synthase, a multi functional enzyme complex, plays a central role in fatty acid synthesis. Its individual activities work in harmony within the complex, allowing for the sequential addition of carbon units and the creation of fatty acids up to 16 carbons in length.

The following are the errors in the information you provided: 00:24 The general formula for monosaccharides is Cx(H2O)x, where x is equal to the number of carbon atoms in the monosaccharide. For example, the structural formula for glucose is C6H12O6, which means that it has six carbon atoms and six water molecules. 01:15 The structural formula for lactose is C12H22O11. This means that it is a disaccharide made up of two monosaccharides, glucose and galactose. 01:39 Polysaccharides are polymers of monosaccharides, but they do not necessarily have to have the same repeating sugar unit throughout. For example, amylopectin is a polysaccharide made up of glucose molecules, but it has a branched structure. Here is a corrected version of the information you provided: Carbohydrates are molecules whose name literally means hydrates of carbon. This is because monosaccharides, the simplest carbohydrates, have a ratio of one carbon atom to two hydrogen atoms to one oxygen atom, the same as water. The general formula for monosaccharides is Cx(H2O)x, where x is equal to the number of carbon atoms in the monosaccharide. For example, the structural formula for glucose is C6H12O6, which means that it has six carbon atoms and six water molecules. Disaccharides are carbohydrates that are made up of two monosaccharides. They are formed by a glycosidic linkage between the two monosaccharides. Disaccharides have the general formula C12H22O11. Examples of disaccharides include sucrose (glucose + fructose), lactose (glucose + galactose), and maltose (glucose + glucose). Polysaccharides are carbohydrates that are made up of many monosaccharides. They are formed by glycosidic linkages between the monosaccharides. Polysaccharides have the general formula (C6H10O5)n, where n is the number of monosaccharides in the polysaccharide. Examples of polysaccharides include cellulose, starch, glycogen, and chitin. Polysaccharides do not necessarily have to have the same repeating sugar unit throughout. For example, amylopectin is a polysaccharide made up of glucose molecules, but it has a branched structure.

Great Lecturer..well explained. Every section of lectures are meticulously explained. Clearly understood.

Simple, not over-complicated and understandable, all great signs of an amazing lecture.

It was a clear and compelling lecture I wish more of the physiology course lectures be like this one

Clear and understandable concept with actual molecules shown aswell which is very helpful.

not explned wel as the topic is difficult and you made it a lot much boring

I really liked and very helpful lectures thank u sir for your explanation

I have really learned. Before, I was wondering why study, or cram all those pathways and enzymes. How Professor Kevin Ahern explains and bring out concepts, Oh my God so great. He was born a teacher and just polished by learning! He never leaves behind any one, even the slow learners can pick, because once one understands the basic, the necessary complex facts can be understood quite faster! I am now thinking of mastering in Biochemistry, besides my goal of Internal medicine. To be the best Physician, Biochemistry I have understood is one of the vital tools! In my Nursing practice, we lost a 10 yr old male with Liver Cirrhosis from a liver disease, which was diagnosed in early age. Now, I am thinking of a Deficiency of the Transaldolase enzyme!! Ahh save for my little knowledge! Kind regards!

Really a great and elaborate presentation. Thanks Prof. Kevin. Now I no longer struggle in cramming Biochemistry but rather find the subject interesting. I wish I started using your lecture guide early in Medical school, but any way not yet late! Thank you once again.

Very dense lecture. Maybe a bit too in-depth in some places, but excellent discussion about the importance of carbohydrates and the key enzymes and reactions that underly the process.

Awesome lectures by Sir. he explain every step and every single reaction with detail thank u.

It was informative in a simple way and the question after make you make sure you got it

I can easily follow the sequence of information. The important details are also emphasized, making it easier for recall.

I really like the explanations and detailed structures used. The structures make it easier to understand.

Very clear and easy to understand. I enjoyed the visuals.

very precise, for a person with basic knowledge it is very helpful although I think it could be a bit difficult to understand for someone who does not know anything about these issues.

The explanation about the carbs are very clear and detail. Which make easier for any student and professor to better understand the carbs, their pathway, and the enzymes that work in those pathways.

This course is easy to understand and memorize. I am 100% recommending this course to anyone in need of learning sciences.

Concepts are very good and explanation is amazing. I'm in love with it

Amino acid MetabolismThe lectures are very thorough and give good details about what is high yield.

I loved this lecture ´cause dr ahern was so clear and it really helped me understand this topic.

It was awesome factual and easy to understand.Amoino acid Metabolism clear relationship to general human Anatomy.

Amazing Dr. Kevin! Thank you very much for this course!

It is Clearly clearly Clearly clearly Clearly clearly Clearly clearly

I loved this lecture! Everything was so well explained: simple, straightforward, and I especially love few external tidbits thrown in such as the meteorite portion. It helps to remember these facts. Thank you!

This lecture was one of my favorites as it made something so confusing perfectly digestible.

The best explanation, Concise and to the point. Thank you so much.

Love this lecture. Dr. Ahern explains much better than my professor.

best explanation of the iron transport on the web that I have come across. Good clear diagrams.

They give clear explanations on all topics in such a way that it is easier to grasp. I personally enjoy learning more about a particular topic and Lecturio is the perfect platform to do that as well. I highly recommend Lecturio to all students for better understanding of relevant topics.

I really appreciate how Professor Ahern broke down this topic (no pun intended). He does a really good job at tying things from other lectures together really bringing these pathways together while also trying to enrich our understanding of the context behind em. Thank you for your hard work!

I honestly had a lot of fun listening to Professor Ahern. You can tell he is really passionate about Biochem. I learned a lot. Great course if you're interested in understanding aspects of the metabolic pathways conceptually while appreciating the details/context that enrich your understanding of them and how they are interrelated.

It was easy to understand, and some details, which i think was enough! not too much information, but enough

He is my favorite instructor by far. His explanations are very good and he is very engaging.

Difficult to memorize all pathways I think it could be more interesting

Comprehensive course with exemplary format & teaching style to explain core concepts.

Aminoacid metabolism Is not easy to understand but still good !!

fast confusing order of explaining Its not like it simlifies anything the way its explained is quite fast and confusing very mono tone

Professor gives a very clear explanation, easily understand. Thank you.

I really understood everything like if it was a brief summary of terms

Its excellent because there is more physical and clinical correlation and enzyme mechanism simplified

I noticed that there weren't any lectures on mineral metabolism in the library. I think students would really appreciate it if you made a module on this topic as it has a lot of biomedical importance and some relevant diseases are associated with it.

Each and every concept is explained with each lecture it has helped me in getting to know things well rather than just learning.

Alright . I think the lecture could be enough for new students

Great explanation about the Bohr effect, thank you very much doctor

Dr. Ahern pointed out very interesting aspects like heat generation/high energy of PEP and the 2,3-BPG production. Maybe I wasn't paying attention the first time I learned about glycolysis, but this extra integrative information it makes this step easier to remember. Actually, in generally, these human focused biochemistry lectures, are easier to digest, since when I learned it originally, it was mixed with plant and microbial biochem.

Prof Ahern explains very well & makes the key steps/enzymes memorable (eg PEP is full of pep!)

So good explications with a nice and simple way . I really appreciate your effort .

I enjoy listening Dr. Raj explanations. He explains it clearly, throws some jokes, and makes conversations with the audience.

Magnificent lecture about polysaccharides and their functions for storage and release

The video highlights the important concepts about the hydrophobic amino acids group

The lectures are very thorough and give good details about what is high yield.

It's unfathomable how much this lecture has saved my time. Though I would appreciate a quick-summary of the products turning into intermediates for other cycles. Like with how g-1-p turns into g-6-p

The lecture simplified glycogenesis to extreme simplicity. It truly helped save around 30 minutes from my lecture, by providing adequate information

very clear explanations and the questions helped me understand the content

It's good, informative not as detailed as I need it to be but it's a good framework to build on

this video is short and easy to understand. Thanks Teacher

I love lecturio, it's the best app in the world. Lecturio has everything you want and can help you to be the best in your class and also be the doctor you want. Lecturio is an opportunity that can give you the change of your student life.

No explanation at all just reading , sorry for that , No interaction

Very good review .enjoyed the enthusiasm. Visuals were ok but not really understood.!

This lecture is amazing and I loved the explanation regarding the conformational change of hexocinase during the reaction.

Teacher speak slowly to help me understand Glucose in my body

me gusto muchísimo lo recomiendo a todo el mundo que quiera saber mas

Sorry, the following videos have the information that I was looking for, sorry again

My professors at university failed to explain lipid metabolism in an understandable manner. Prof Ahern does a great job in explaining complex topics and I am really grateful for that. Thank you

Very good and simple to follow. Makes learning easy. Great.

It almost always fails to explain 'why'. These lists are available in any textbook. I was looking for an explanation to understand it. Also, visually it is looking at a table for 5 minutes, pictures could have explained better.

Kevin sir explanation is very very nice and it's an extraordinary talent and explanation but little more information should be presented in power point slides so that we can learn more and more by step by step .. Thank you sir From Sanjeev India

It's very good i appreciate this hard work by the innovation

Whenever I get confused about a pathway, I come to watch these videos and it helps tremendously. Thank you for what you do.

I find the teaching style to be effective and well planned. I use lecturio for supplimenting the topics taught in my classes

Very insightful and brilliant explanation. I learned very much in this lecture! School professor just skip much of the importance in PPP!

Excellent lecture, well explained so I could understand it. So important to understand and not just memorize these topics.

Excellent lecture. Understood Bohr effect better than ever. I love these lectures.

This videos are amazing, the professor is excellent and his explications are clear

He is a very Good Teacher as he teaches as if he was narrating a story.

Thanks Mr Kevin for your time, dedication and preparation, blessings my man!!! happy 2020

Amazing explanation made me understand the concept clearly in a short time

two stars just for the effort. But its ore like reading fro book. Nothing different. Very boring. No interaction.

Great professor. Has almost everything needed for my course in Biochemistry.

this lecture covers almost everything I need to know to learn about th adrenal before stepping into its pathology

Muy buen docente, se nota que le apasiona su profesion y la ejerce con entusiasmo.

A huge thank you to Prof Ahern! You explanations are very easy to understand and your lectures are a huge help to get a better understanding of biochemistry topics. Thank you very much!

Really good discussion. I would love Dr. Ahern to by my mentor

It is a great parsimonious source for understanding the mechanism in which amino acids build into protein and how amino acids are broken down through metabolism into various molecules inside the body. The lecture also provides the structural frame understand the basics of amino acid regulation through metabolism.

Simply explained with a little history that made it fun and also helps keep the connection to the content, So much of medical knowledge is facts and figures which can easily become blurred in my mind. The connection to history helps this content stand out in my head! Thank you!

Very high-yield. Thank you for underlining this moment, crucial in treating hypercholesterolemia.

A+ teaching style and delivery thank you Dr Ahern for making a difficult topic easier to digest

Love Raj’s speaking and teaching style: very conversational but professional and easy to follow. It’s like you’re face to face in a real lecture with him. I like all of his lectures!

it is really amazing lecture & has been organized well thank you

Clear and Comprehensive explanation. Not too detailed but enough to understand.

Very much explaining After I did this topics know is easy to undeerstanding

extremely helpful when the amino acids are divided in functional relevance.

This lecture was explained super clear and to the point. Thank you!

:) Thank you . everything in this lecture is clear. like it very much.

Very eloquent :) my favorite on this website! would definitely recommend.

This video did not really show Aspartic Acid or Glutamic Acid?

He very easily simplifies things. So this is why I give him a five star review

amazing ! thank you so much dear dr.Ahern , i was always scared of biochemistry ,but its the first time i finally get to understand it and i owe it all to you. My committee exam will be in two weeks and im hoping to finish this course plus few more lectures from fat metabolism course. also special thanks to lecturio for preparing such a great learning system opportunity for us.

Awesome lecture, awesome proffesor. My teacher spent almost 1 hour explaining that. Thank you Dr. Ahern

For the first time ever, I got AA right. Thank you!

I'll just say thank you very very very very much!!!

Love him so far, clear concise and to the point and also very enlightening

Yea, these lessons site wide need more quiz questions. Only thing holding this site back from being outstanding.

way too fast ????I really wish the teacher would talk slower as now I keep having to pause and rewind etc.

Easy to understand and the explanation are very clear. Thank you very much good job!

Needs more details, and take it slower so that we the audience can get a more thorough understanding of the topic (the video really doesnt need to be that short)

I found it really helpful. Your explanations were clear and easy to understand.

Thank you for the video's theses are really helpful. look forward to keep learning.

Very good lecture, l consider that is one of the most complete themes that l´ve read ...good job.

This entire series is the most eloquent and beautiful explanation of a terrible terrible subject like biochemistry I have ever seen to attended

I find Dr. Thad Wilsons lectures concise and interestingly put, leading to easy proper revision. Thank you

Had so much difficulty learning the enzymes on the pathways. This way was easy to understand it!!

Explanation is crystal clear. Slightly fast for the beginner, but repeating the video would help. Thanks.

Wonderful! An awesome lecturer, he just has a unique way of passing the message. Great work Sir

He explains it very well and at a good speed. He doesn't use to many difficult words so if your first language isn't english it's still possible to understand. Also whenever you have a question he answers quickly en thouroughly.

i like your teaching .sir. it helps me to understand the concepts clearly.

Great lecturer very knowledgeable of subject matter at an admirable pace. Needed this in depth type of lecture in med sch. Good job

Great lecturer very knowledgeable of subject matter at an admirable pace. Needed this in depth type of lecture in med sch. Good job

Great lecturer very knowledgeable of subject matter at an admirable pace. Good job

Es un excelente profesor ya que es muy específico en la antomía, me gusta el sentido en el que va mencionando cada parte del organo y la función que cumple asi como sus patología so anomalias en cuestiones anormales

Thank you very much! Those extraordinarily awesome questions help me better understand the whole thing with details!

Wow, these two amines are very tricky, thank you very much, Prof. Ahern!

I cannot believe I am just now finding this resource during my dedicated Step 1 period. However, I am so glad that I found it now, right at the beginning of Step prep, rather than later. I plan to use this as one of my main resources for the remainder of time up until my exam. I realized while reading First Aid that, although I had known the subjects very well at one point, that my foundation was not as solid as it once was. This is perfect for reviewing and providing the big picture for everything. It's also an amazing resource for providing the "why" and "how" behind all the small factoids written in First Aid which is just what I need. It's so much easier to retain the information when you actually understand what is going on rather than memorizing a 650+ page book of bullet point lists/facts. This is great. I was a huge fan of Boards and Beyond, but I have since ditched that resource and am fully focusing on this one since this seems a lot more comprehensive and better taught (though Dr. Ryan has also done an amazing job too). Thank you guys so much for coming out with such a well thought out and developed and thorough resource. This is going to make board prep so much smoother. If I end up scoring highly on Step 1, I will make sure to write a review on Reddit, SDN, etc raving about Lecturio.

This guy just knows his stuff, on point even with the speed of his speech he has mastered his slides. I almost got scared with the previous lecture in genetics but he managed to bring me back home. Very knowledgeable keep up the good work and add more clinical correlations.

I LIKE THE PRESENTATION AND I LEARN . PROFF. USE A SIMPLE AND UNDERSTANDABLE LANGUAGE

Its really interesting subject made easy by an interesting professor. I'm not sure if that level of details are needed for the USMLE exam as I'm using the USMLE curriculum, if its not needed thats fine it will be for my future knowledge hopefully if i get to keep in my head.

It was simply amazing. The knowledge I got exposed to was simply clear cut and delivered by an expert in layman's literature. I am keen to absorb more of Mr. Kevin Ahern's lectures.

Batalle mucho para entnder mis clases pero con estén curso tengo un mejor dominio de el metabolismo y me permitió realizar una presentacion del tema ????

Great video. I just would like if it talk more about the similarity between receptors (Alpha units)

Recommend this course to any medical students doing pre/clinical Helps with pathways and understanding breakdown.

best and easy way to revise. Dr Thad Wilson has the best way of explaining things. appriciated

Excellent! Well delivered and full of quality information. Totally recommend this course.

Dr. Ahern was very clear and concise. Great lecture. Thank you!

Amazing lecture and slides explained very well and it was useful to have the slides downloaded.

I finally understood why keto diet is so effective :) Thank you Dr. Kevin!

Explains everything extremely clearly and made all of the processes easy to understand. This was a great lecture series!

this is very helpful. thank you very much for this lecture.

The Good: Lecture: 5/5 Amazing Lecture! I learned a lot! The Not so good: Quiz:2/5 Only 1 question....and was not as specific as I would like it to have been. Perhaps consider having at least 50% of the terms discussed included in the Quiz.

The subject is really hard... but the professor is excellent!

Thank you Dr Ahern! Thanks to your clear and nice explanations With integrations I am finally starting to understand Biochem! You make difficult things look so simple and enhances the importance and intelligence of mother nature in our human bodies

Incredibly good! I have spent hours studying from the book and this is by far the most helpful in terms of deep,meaningful understanding of the subject.

Need more details Need to go slower But overall not bad

The lecturer is very good at getting biochemistry across. Well explained and understandable up and until here.

Kevin must be the best teacher ever. He explains with a certainty only a person with many years of lecturing can. Simple, easy and fast, making complicated matters seem easy to learn. Compared to the slides i have in med. school, the content is the same. But this guy also gives the explaination in the same amount of time! His body language is also nice to watch as they are firm and open, kind of directing your thoughts, like a maestro. You just have to remember and do some repetition of EVERY detail he mentiones, it will for sure be on the exam. I also use his lectures to simplify my understandings from pdf files from school and heavy textbooks. I will recommend everyone to use this!! Also i love the quiz afterwards. 1rst year university medicine

Very clear summary. Would like to see more clinical correlations made.

I like the way that the AA are presented by a table between essentiel and non essential. I will use it for my memorizing process.

This lecturer is inarticulate and speaks very fast. I'm having difficulty keeping up with him.

he is so good ... I am very thankful to you sir !!

Easy to understand with the structure of the molecule. Very clear and straight forward.

Great Instructor. Clear, concise, very easy to comprehend. Dr. Ahern gives the "meat" of the concept. Not long winded.

Awesome job, I wish you were my teacher at my university! So clear!

I subscribe because of this professor. Great lectures and explanation. Nice job

important points are marked and forces one to be carefull of the whole sentence

I am a high school biology student and this helped me so much thank you!

Very clearly explained. Doctor Raj makes things easy and entertaining. Thank you. PS: i love how he connects the theory with the clinical practice.

The professor was very clear and his tone was lively :)

I was impressed by the knowledge of the professor. However, the very short length of each lecture was disturbing and distracting.

this guy so good only amazing so much only omg nice nice

Great professor, great explanations. This video was like a summary of important parts.

it's too summarized & there's not enough questions in the the qbank

it was very good lecture it will help me in my med biochem class thanku

Excellent explanation, detailed enough to understand the main pathways and its regulation

Exactly what I needed. Straightforward and to the point. Linearly organized.

Very helpful Keep it up .. easy to understand . Lecture in a simple way

Hello though I learnt new things by the good explanation of the pathway but I will be happy if there could be mnemonics to remember then easily. Thanks

Thank you very much for such a great lectures!Biochemistry have never been so interestig until now)

Informative lecture, was going a little bit too fast but repeating the video helped.