Review of Clotting (Nursing)

00:01 Now let's talk about the three types of serum proteins.

00:04 Liver disease or a damaged liver can cause a decreased amount of all three of these proteins.

00:10 Now albumin is produced in the liver.

00:12 So you see in the plasma we've got albumin right there for you.

00:17 Globulin, they're made by the liver while others are made by the immune system.

00:22 But so far in our picture you see albumin and then you've got the globulins.

00:26 Again, don't memorize those.

00:28 We're just putting this up here as a visual so you can get a good good framework of what we're talking about.

00:32 Now I promised you a three types of serum protein, one was albumin the second or the globulins, but I want to zero in on fibrinogen.

00:42 Now, you see that over on the right of your screen.

00:45 It's produced in the liver.

00:47 We've got the normal values there, again just as a frame of reference, but take away from this slide three types of serum protein albumin, globulins, and we're going to focus in on Fibrinogen.

01:02 So let's take a look at that fibrinogen.

01:04 I've got a picture up there to help you kind of make sense of it.

01:08 This is how a clot forms.

01:09 Now remember fibrinogen is one of three important proteins that the liver makes so the serum proteins are made in the liver.

01:17 But disease livers don't make them very well they don't make enough adequate amounts of these proteins.

01:23 So fibrinogen is one of the coagulation factors one of the things that helps make a normal blood clot.

01:30 Now it's converted by thrombin into fibrin which helps build a clot.

01:35 So look at the bloodstream, you've got there.

01:36 Let's pretend up at the top there.

01:38 We've got damage to that blood vessel.

01:41 So what normally happens you see we've got flowing through here.

01:43 We've got red blood cells.

01:45 We've got leukocytes otherwise known as white blood cells and you see some platelets.

01:50 Now, we've got this fibrinogen that's turned into fibrin and that kind of gives us this net that's catching everything.

01:57 That's how it starts to collect and weave this plug that will cap off and stop bleeding because remember fibrinogen is converted into thrombin by fibrin which helps us build a clot.

02:11 Perfect, all right, so see the picture there, you've got the idea, we have damaged then we have the fibrinogen is what helps us kind of build this web to collect the platelets and the other blood cells to help heal and fix that leaky area of the blood vessel.