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The lecture Diabetic Ketoacidosis with Case by Michael Lazarus, MD is from the course Diabetes Mellitus. It contains the following chapters:
What is the significance of an undetectable c-peptide level in a patient?
By what mechanism are ketone bodies produced?
What is the most likely diagnosis in the case described below? A 10-year-old boy is brought to the emergency department by his mother because of frequent vomiting, abdominal pain, and weakness. Over the last 5 days, he felt excessively thirsty and has been urinating frequently. Family history is noncontributory. Physical examination results: Temperature is 37.1°C (98.7°F), blood pressure is 100/70 mm Hg, pulse is 110 beats/min. He is nonresponsive to verbal commands and has sunken eyes; poor skin turgor; and rapid, deep respirations. Laboratory test results: Random plasma glucose level of 460 mg/dL, undetectable fasting C-peptide, elevated serum beta-hydroxybutyrate level, and positive results for antiglutamic acid decarboxylase (GAD) antibodies
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