00:00
Let's talk a little bit about the chronic complications of diabetes mellitus. We'll review
cardiovascular morbidity, diabetic nephropathy, diabetic foot ulcers, diabetic retinopathy,
diabetic neuropathy, and finally the syndrome of hypoglycemic unawareness. In terms of
cardiovascular disease, diabetes alone is an independent risk factor. It is considered a
cardiovascular disease equivalent. Concomitant risk factors in patients with diabetes such as
hypertension, obesity, and dyslipidemia also contribute to the development of underlying
cardiovascular disease. It can be identified through early screening. Hypertension and diabetes
mellitus has different parameters in terms of treatment. Treat systolic blood pressure goals of
less than 130 mg and a diastolic blood pressure goal of less than 80. Drug classes that are
demonstrated to reduce cardiovascular events in patients with diabetes include the ACE inhibitors,
the angiotensin-receptor blockers, thiazide diuretics, or dihydropyridine calcium channel blockers.
01:13
Measure the blood pressure at every visit and also suggest home monitoring for patients. With
regards to hyperlipidemia and diabetes mellitus. If cardiovascular or other vascular disease is
known, give high intensity statin therapy. If no cardiovascular disease is known, provide high
intensity statin therapy to patients with diabetes. If the LDL cholesterol level is greater than
190 mg/dL or the 10-year American Society of Cardiovascular Risk is greater than 7.5%. Provide
moderate intensity statin therapy for patients with diabetes who have a 10-year ASCVD risk less than
7.5%. Let's talk a little bit about diabetic retinopathy. This is the leading preventable cause of
blindness in adults age 20-74. The risk factors include long-term diabetes, poorly controlled
diabetes, concomitant hypertension, and nephropathy. Diabetic retinopathy is broken down
into non-proliferative and proliferative forms. The non- proliferative or less severe form results
from the leaking of fluids through blood vessels in the eye and leads to blurry vision. Signs of
mild to moderate non-proliferative retinopathy include microaneurysms, intraretinal hemorrhages,
cotton wool spots, and lipid exudates. Severe non-proliferative retinopathy is characterized
by venous beading, intraretinal microvascular abnormalities, and widespread intraretinal
hemorrhages. The proliferative form on the other hand is the advanced form of disease. This is
characterized by the new growth of blood vessels in the eye otherwise known as neovascularization.
03:06
These are weak and can therefore bleed easily. They can also cause retinal scarring and lead to
visual loss. In these images, we see the right eye and the left eye manifesting diabetic macular
edema. On the background of the retina, the light spots are exudates. There is no evidence of
near blood vessel formation so this is more likely a non-proliferative diabetic retinopathy.
03:35
In contrast to that, the images here demonstrate significant hemorrhages on bilateral retina
which are significant for a more severe form of non-proliferative retinopathy. In terms of
management of diabetic retinopathy, optimal blood glucose and blood pressure control are
very important. Focal laser photocoagulation of the retina may also be necessary. Panretinal laser
photocoagulation reduces continued vision loss in proliferative diabetic retinopathy and severe
non-proliferative diabetic retinopathy. Let's move on to discussion of diabetic nephropathy.
04:15
Measurement of increased protein excretion can be performed by 2 methods. The albumin-creatinine
ratio on a random spot urine collection or a 24-hour urine collection. Persistently elevated levels
of urine albumin excretion greater than or equal to 30 mg/g in a spot urine measurement or
30-299 mg/24 hours or greater than or equal to 300 mg/24 hours. Urine albumin levels should
be elevated on multiple samples over 3-6 months to diagnose albuminuria as false positive elevations
can occur in the setting of illness, menstruation, recent exercise, extreme hypoglycemia, or
hypertension and heart failure. Annual measurements of serum creatinine and an estimated glomerular
filtration rate can be utilized in conjunction with the urine albumin measurements to determine
the stage of chronic kidney disease. When the estimated GFR is less than 30 mL/min/1.73 m2, a
referral to a nephrologist is recommended. Prevent or delay the progression of diabetic kidney
disease with optimal plasma glucose and blood pressure control. In non-pregnant normotensive
patients with persistently elevated urine albumin excretion, the recommendation is to start an
ACE inhibitor or an angiotensin receptor blocker to decrease progression of nephropathy. In
non-pregnant hypertensive patients with persistently elevated urine albumin excretion and
and hypertension, titration of the ACE inhibitor or ARB o achieve blood pressure goals of less
than 130/80 mmHg.