Steroids and Bile Acids: Mevalonate Pathway II
About the Lecture
The lecture Steroids and Bile Acids: Mevalonate Pathway II by Kevin Ahern, PhD is from the course Lipid Metabolism.
Included Quiz Questions
Which of the following is a cyclic intermediate produced during cholesterol synthesis?
- Lanosterol
- Squalene
- Farnesyl pyrophosphate
- Geranyl pyrophosphate
- Dimethylallyl pyrophosphate
Which of the following statements is FALSE regarding cholesterol synthesis in the body?
- Isopentenyl pyrophosphate (IPP) and dimethylallyl pyrophosphate (DMAPP) are produced from HMG-CoA by the action of the enzyme HMG-CoA reductase in the presence of lanosterol.
- The conversion of HMG-CoA to mevalonate is mediated by an enzyme called HMG-CoA reductase.
- Cholesterol regulates the production of HMG-CoA enzyme through feedback inhibition.
- HMG-CoA reductase enzyme plays a very important role in the regulation of cholesterol synthesis in the body.
- Statin drugs act as competitive inhibitors of HMG-CoA reductase, so it is useful as a cholesterol-lowering drug.
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Author of lecture Steroids and Bile Acids: Mevalonate Pathway II
Kevin Ahern, PhD
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