Sequencing Larger Genomes
About the Lecture
The lecture Sequencing Larger Genomes by Georgina Cornwall, PhD is from the course Genomics.
Included Quiz Questions
Which sequencing method is used to cut the DNA of an entire chromosome into small fragments, clone them, and arrange the overlapping sequences?
- Shotgun sequencing
- Clone-by-clone sequencing
- Consensus sequencing
- STS sequencing
- BAC-to-BAC sequencing
Which of the following best describes the clone-by-clone sequencing method?
- Cloning of larger chromosomes and then subcloning them into smaller pieces for sequencing
- Cloning of smaller DNA molecules into a plasmid for sequencing
- Cloning of viral DNA molecules into a human chromosome for sequencing
- Cloning of plasmid DNA molecules into a human chromosome for sequencing
- Cloning of bacterial DNA molecules into a human chromosome for sequencing
Which of the following statements is NOT true regarding the shotgun method of sequencing?
- The shotgun method of sequencing works well with highly repetitive types of DNA molecules.
- The whole-genome shotgun method involves the sequencing of overlapping DNA fragments in parallel and assembling small fragments into larger fragments and then into chromosomes by using a computer program.
- The whole-genome shotgun method is rapid and straightforward versus the clone-by-clone sequencing method.
- Any genome with a lot of repetitive sequences is associated with difficulties during chromosome assembly.
- A genome with few repeated regions can be easily and rapidly sequenced using the whole-genome shotgun method.
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Author of lecture Sequencing Larger Genomes
Georgina Cornwall, PhD
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