00:01
Alcoholic Liver Disease
Yet, another cause of Hepatitis.
00:08
good at some point in time.
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Now, with that said,
a little bit of biochemistry and basics
Also, what may then happen in end-stage.
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Alcoholic Liver Disease,
you have a patient that’s drinking beer, how much?
Well, for a female, greater
than 20 g per day for a woman.
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Whereas for men, greater than 40 g per day.
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Because of the increase amount
of metabolism that males have inherently.
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Long-term excessive use can cause
a range of Alcoholic Liver Disease.
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What I'm trying to say is this:
You can have a patient who has been drinking
and most of us will then cause fatty change
or we call this Hepatic Steatosis.
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But you could have patients
that drink alcohol,
Instead of having fatty change
which is reversible,
there is a possibility that it might go into
what is known as Alcoholic Hepatitis.
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So, from henceforth,
when you're dealing with Alcoholic Liver Disease
you can divide this into three
major diseases.
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and it doesn't even have to follow in steps.
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You don't have to go from fatty change
to Alcoholic Hepatitis to Cirrhosis.
01:25
You don't have to go from fatty change
to Alcoholic Hepatitis the Cirrhosis
You can have a patient who is drinking
and go straight into Alcoholic Hepatitis;
You've heard of Mallory bodies.
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Or you can go directly into Cirrhosis,
worst-case scenario.
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Make sure you understand as to
how much alcohol is excessive.
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Risk factors. As we said earlier,
A female unfortunately,
would have decreased equipment
to metabolize the alcohol effectively.
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Therefore, she might be at risk
for alcoholic liver disease.
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Malnutrition, underlying viral hepatitis.
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Remember, the if you have
a patient of viral hepatitis
in this then to you an increase in ALT
and this patient, remember,
a patient who has hepatitis C,
who has chronic hepatitis, most likely,
asymptomatic on top of that,
and starts drinking, will only
exacerbate the disease further.
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Risk factors are important
for you to understand.
02:25
Alcoholic Liver Disease.
02:27
The types and the syndromes
that we will take a look at.
02:31
What I am not be covering
here in great detail
which we did in basics,
is the accumulation
of triglycerides in your liver
and it's called your fatty change,
you call that Hepatic Steatosis.
02:42
I'll go straight into your clinical syndromes
for Alcoholic Liver Disease.
02:46
I will talk about Alcoholic Hepatitis.
and I will talk about Alcoholic Cirrhosis.
02:50
Is that clear?
Under biochemistry,
extremely important that you know
about proper alcohol metabolism
and enzymes and their genetics.
03:00
For example, the first enzyme
that is required for proper alcohol metabolism
if you remember correctly,
It's called Alcohol Dehydrogenase.
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The second enzyme
that you absolutely must know
from even pharmacology management
is then called Aldehyde Dehydrogenase, right?
What’s the drug that
I am referring to that inhibits
Aldehyde Dehydrogenase-
disulfiram.
03:22
Another topic.
03:24
A different subject.
03:25
Here, under pathology,
I will walk you through the clinical syndrome
of Hepatitis of Alcohol,
and Cirrhosis caused by alcohol.