Catabolism of Guanine & Hypoxanthine and Purine Nucleotide Salvage
About the Lecture
The lecture Catabolism of Guanine & Hypoxanthine and Purine Nucleotide Salvage by Kevin Ahern, PhD is from the course Purine and Pyrimidine Metabolism. It contains the following chapters:
- Catabolism of Guanine and Hypoxanthie
- Purine Nucleotide Salvage
Included Quiz Questions
Which of the following occurs in the catabolism of hypoxanthine?
- Allopurinol inhibits xanthine oxidase.
- Xanthine oxidase catalyzes the conversion of guanine into xanthine.
- Uric acid is formed directly from guanine.
- Guanine is converted to hypoxanthine by guanase.
- Allopurinol inhibits guanase.
Which of the following is true regarding gout?
- It is caused by crystals of uric acid.
- High hypoxanthine concentrations cause gout.
- Gout patients have a higher than average incidence of multiple sclerosis.
- It is worsened by allopurinol.
- It may be cured with a purine-rich diet.
Which of the following is true regarding the salvage synthesis of purine nucleotides?
- It results in Lesch-Nyhan syndrome if HGPRT is absent.
- It includes only the purine bases.
- It requires ribose-5-phosphate as a source of ribose.
- Guanine is unable to participate in this salvage pathway.
- Adenine is unable to participate in this salvage pathway.
Which statement is true regarding Lesch-Nyhan syndrome?
- Lesch-Nyhan syndrome occurs due to a deficiency of hypoxanthine-guanine phosphoribosyltransferase enzyme.
- Lesch-Nyhan syndrome is inherited in an autosomal recessive manner.
- Lesch-Nyhan syndrome has a good prognosis and patients recover by the second decade of life.
- Lesch-Nyhan syndrome is associated with a deficiency of uric acid in all the body fluids for the patient suffering from HPRT gene on the X-chromosome.
- Lesch-Nyhan syndrome is not associated with neurological problems.
Which statement is true regarding allopurinol?
- Allopurinol is used in the treatment of gout because of its ability to inhibit uric acid production.
- Allopurinol is a pyrimidine analog.
- Allopurinol is an activator of the enzyme xanthine oxidase.
- Allopurinol enhances the synthesis of urea from the uric acid by activating the enzyme xanthine oxidase.
- Allopurinol inhibits the salvage of hypoxanthine and xanthine to purine ribotides.
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Author of lecture Catabolism of Guanine & Hypoxanthine and Purine Nucleotide Salvage
Kevin Ahern, PhD
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Amazing way of teaching, compact and efficient. Really good job, keep doing it Mr. Ahern.
Fantastic lecture, just the amount of information I needed to cover and retain the topic.
