G-protein Coupled Receptors – Second Messenger Systems
About the Lecture
The lecture G-protein Coupled Receptors – Second Messenger Systems by Georgina Cornwall, PhD is from the course Cellular Structure.
Included Quiz Questions
Which of the following signaling cascades are in the correct sequence?
- G protein alpha-subunit → adenylyl cyclase → cAMP → PKA → response protein
- G protein alpha-subunit → cAMP → adenylyl cyclase → PKA → response protein
- G protein alpha-subunit → adenylyl cyclase → PKA → cAMP → response protein
- G protein alpha-subunit → PKA→ cAMP → adenylyl cyclase → response protein
- G protein gamma-subunit → adenylyl cyclase → cAMP → PKA → response protein
Which of the following is responsible for the production of cAMP in a G protein–coupled receptor system?
- Adenylyl cyclase
- Guanylyl cyclase
- Phosphokinase
- Protein phosphatase
- Protein diphosphatase
Which of the following is NOT correct regarding phosphatidylinositol-4,5-bisphosphate (PIP-2) and signal transduction?
- Diacylglycerol (DAG) and inositol-1,4,5-triphosphate (IP3) are signal-carrying molecules that bind to the cell membrane receptor during muscle contraction.
- PIP-2 is a membrane phospholipid embedded in the inner leaflet of the cell membrane.
- DAG and IP3 act as second messengers in downstream signaling pathways.
- Phospholipase C acts as an effector protein and hydrolyzes PIP-2 to propagate the muscle cell contraction signaling cascade.
- IP3 and DAG stimulate downstream signaling pathways to facilitate hormone release in endocrine cells.
Which of the following is CORRECT regarding the effect of epinephrine?
- Epinephrine stimulates G protein–coupled receptors in the heart to increase contractions.
- Epinephrine stimulates G protein–coupled receptors in the heart to decrease contractions.
- Epinephrine stimulates G protein–coupled receptors in the small intestines to increase contractions.
- Epinephrine stimulates G protein–coupled receptors in the small intestine, which activates adenylyl cyclase.
- Epinephrine stimulates G protein–coupled receptors in the heart, which inactivates adenylyl cyclase.
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Author of lecture G-protein Coupled Receptors – Second Messenger Systems
Georgina Cornwall, PhD
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It was a great lesson thanks for everyting short and briefly everyting.
