ANCA-associated Small Vessel Vasculitides
About the Lecture
The lecture ANCA-associated Small Vessel Vasculitides by Carlo Raj, MD is from the course Vasculitis: Basic Principles with Carlo Raj.
Included Quiz Questions
A 54-year-old man presents with hematuria, hemoptysis, and sinusitis. He has no history of a serious illness and takes no medications. Laboratory studies are positive for anti-neutrophil cytoplasmic antibodies (ANCA). Which of the following conditions is the most likely diagnosis?
- Granulomatosis with polyangiitis
- Takayasu arteritis
- Giant cell arteritis
- Polyarteritis nodosa
- Eosinophilic granulomatosis with polyangiitis
PR3-ANCA (anti-neutrophil cytoplasmic antibody) is most characteristic of which of the following diseases?
- Granulomatosis with polyangiitis
- Polyarteritis nodosa
- Churg–Strauss syndrome
- Rapidly progressive glomerulonephritis
- Henoch–Schönlein purpura
Which of the following is NOT a typical drug in the induction and/or maintenance therapy of granulomatosis with polyangiitis?
- Heparin
- Glucocorticoids
- Methotrexate
- Cyclophosphamide
- Rituximab
Which of the following statements regarding granulomatosis with polyangiitis is FALSE?
- Renal involvement is more common than upper airway involvement.
- PR3-ANCA (anti-neutrophil cytoplasmic antibody) is positive in the majority of patients.
- Renal biopsy often demonstrates a pauci-immune glomerulonephritis.
- Small vessels are most commonly affected.
- There can be necrotizing destruction of the nasal septum.
A 70-year-old man presents with vasculitis of the lungs and kidneys without significant upper airway involvement. Myeloperoxidase-antineutrophil cytoplasmic antibodies (MPO-ANCA) are positive, but PR3-ANCA is negative. Biopsy reveals pauci-immune glomerulonephritis without granulomas. Which of the following is the most likely diagnosis?
- Microscopic polyangiitis
- Granulomatosis with polyangiitis
- Goodpasture syndrome
- Polyarteritis nodosa
- Eosinophilic granulomatosis with polyangiitis
Which of the following markers is most frequently present in a patient with microscopic polyangiitis?
- Myeloperoxidase-antineutrophil cytoplasmic antibodies (MPO-ANCA)
- Proteinase 3-antineutrophil cytoplasmic antibodies (PR3-ANCA)
- Anti-double stranded DNA
- Anti-centromere antibodies
- Anti-cyclic citrullinated peptide
What is the most likely diagnosis in a patient with a history of drug-resistant asthma, recent pulmonary infiltrates and hemoptysis, mononeuritis multiplex, palpable purpura, and peripheral blood eosinophilia?
- Churg–Strauss syndrome
- Granulomatosis with polyangiitis
- Microscopic polyangiitis
- Takayasu arteritis
- Asthma
Author of lecture ANCA-associated Small Vessel Vasculitides
Carlo Raj, MD
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I always know its going to be a good lecture when I see Dr. Raj teaching it
Mehmet K, and others thank you for your feedback! I hope this message finds you and your loved ones safe in 2021. I read your comments, and try to deeply reflect upon them. I thoroughly enjoy the feedback that I receive from you the medical students and doctors, fore; it allows me to improve upon the art that I have been fortunate enough to be part for the past 20 years. Thanks to individuals such as you who take the time out of your busy schedule to express what is on your mind, it allows me to always be improving as a medical educator. There are numerous other resources out there, as you are aware, and I feel privileged that you wish to invest your time and money with me and Lecturio. As any patient should receive 2nd and 3rd opinions about treatment protocol, and even encourage such behavior by doctors who are secure in themselves, I would recommend the same for you so that you are constantly being fed and inspired by medical knowledge! You live in golden age of medical education and possess tools at your disposal to excel in your medical school coursework, USMLE/PLAB/MER, etc. I hope you find a resource that you can relate to, if it's me, fantastic, if not, that's okay too, but the most important thing is that you/me, WE, continue on our journey of growth and humility. Thank you all for making me a part of your academic life, however brief it may be. ~Carlo Raj
this doc has a disgusting accent and teaching method. weird jokes and attitudes. if lecturio would like to improve itself, the very first thing is to sack this man and find a proper lecturer like anesthesiologist one.
