Pharmacology Question Set 1

A 45 year old male presents with a chief complaint of pain in the great toe. He has a past history of gout, which was under control. He is known diabetic for the past 5 years and is currently taking metformin. He was recently diagnosed with hypertension and was placed on a hypertensive drugs. He is a non-smoker and non-alcoholic. His family history includes, father having ischemic heart disease. His current BP is 136/84 mm Hg, pulse 78/ min. Systemic examination is negative for any abnormalities. He also uses over the counter (OTC) multivitamin supplements. Which of the following drugs might have resulted in the presentation of these symptoms?

An experimental new drug SD27C is being studied. This novel drug delivers insulin via intranasal route. Consent is taken from participants who are diabetic and taking insulin as their current treatment regimen to participate in the clinical trial. 500 patients consent and are divided into 2 groups and a double blind clinical trial was performed. One group received the new formulation SD27C, while the second group received regular insulin via subcutaneous injection. The results found out that the treatment outcomes in both the groups are the same. SD27C is currently performing which phase of clinical trial?

A 14 year old male presents to the emergency department with severe abdominal pain, nausea and vomiting. He is disoriented to time and place and shows Kussmaul breathing. Abdominal examination showed generalized tenderness without guarding and rigidity. His vitals include BP of 104/64, pulse is 92/min. Labs show a random glucose level of 628 mg /dl, pH of 7.1, pCo2 of 23 mmHg, Serum ketones are positive, Serum Na is 126 mEq/L, Serum Potassium is 5.2 mEq/L, Serum bicarbonate is 13 mEq/L. Which of the glucose transporter is nonfunctional in this person?

An experimental new drug in the treatment of diabetes mellitus was found to increase the levels of incretins by preventing the degradation at the endothelium. It further increased the glucose dependent insulin production. Its action is most likely similar to which drug?

A 34 year old male presents to the outpatient department with a complaint of right sided jaw pain. Each episode of pain lasts for about 30 seconds. This has lasted for the last month but has increased in the number of episodes per day which has brought her to the clinic. The mechanism of action for the drug of choice for this patient is?

A 45 year old female presents with the complaint of pain in the metacarpophalangeal joints and proximal interphalangeal joints bilaterally. Serology showed positive anti-CCP antibodies. She was placed on infliximab for control. Which of the following need to tested before starting treatment?

A 46 year old female was presented with a complaint of increased palpitations, tremor and anxiety. She has been observing these symptoms after a recent change in her diabetic medication. Last time she felt these symptoms here blood glucose was 65 mg/dl and she felt better after eating a cookie. The mechanism of action of the drug which resulted in these symptoms likely:

A 32 year old male presents to the outpatient clinic for prophylaxis he need to take before leaving trip to Asia which is endemic to tuberculosis. His Mantoux test is positive but has negative findings on chest X-ray and AFB sputum culture. He was placed on Isoniazid. The most likely mechanism of resistance in Isoniazid is?

A 27 year old male presents to the outpatient clinic with a swollen and painful great toe. The pain intensity increased more after he went to a party last night. The drug of choice for this patient is?

A 52 year old female complains of severe vomiting since past 2 days. She recently had a chemotherapy session for her breast cancer. The most likely mechanism of the drug which prevents chemotherapy induced vomiting is?